TCR engagement negatively affects CD8 but not CD4 CAR T cell expansion and leukemic clearance-Reference-Cited by-同舟云学术

TCR engagement negatively affects CD8 but not CD4 CAR T cell expansion and leukemic clearance

Published:2017-11-22 Issue:417 Volume:9 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Yang Yinmeng¹²^ORCID,Kohler M. Eric¹³,Chien Christopher D.¹^ORCID,Sauter Christopher T.¹^ORCID,Jacoby Elad¹^ORCID,Yan Chunhua⁴,Hu Ying⁴,Wanhainen Kelsey¹,Qin Haiying¹^ORCID,Fry Terry J.¹^ORCID

Affiliation:

1. Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

2. Lombardi Comprehensive Cancer Center, Department of Oncology, Georgetown University, Washington, DC 20057, USA.

3. Departments of Pediatric Oncology and Pediatric Hematology, Johns Hopkins University, Baltimore, MD 21287, USA.

4. Center for Biomedical Informatics and Information Technology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

Abstract

TCR engagement induces CD8 CAR T cell exhaustion and poor in vivo functionality in mice.

Funder

National Institutes of Health

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference41 articles.

1. Biology of Childhood Acute Lymphoblastic Leukemia

2. Acute Lymphoblastic Leukemia

3. How I treat acute lymphoblastic leukemia in older adolescents and young adults

4. Efficacy and Toxicity Management of 19-28z CAR T Cell Therapy in B Cell Acute Lymphoblastic Leukemia

5. Chimeric Antigen Receptor T Cells for Sustained Remissions in Leukemia

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