Loss of dual leucine zipper kinase signaling is protective in animal models of neurodegenerative disease-Reference-Cited by-同舟云学术

Loss of dual leucine zipper kinase signaling is protective in animal models of neurodegenerative disease

Published:2017-08-16 Issue:403 Volume:9 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Le Pichon Claire E.¹^ORCID,Meilandt William J.¹^ORCID,Dominguez Sara¹,Solanoy Hilda¹,Lin Han¹^ORCID,Ngu Hai²,Gogineni Alvin³^ORCID,Sengupta Ghosh Arundhati¹,Jiang Zhiyu¹,Lee Seung-Hye¹^ORCID,Maloney Janice¹^ORCID,Gandham Vineela D.³^ORCID,Pozniak Christine D.¹^ORCID,Wang Bei¹,Lee Sebum⁴^ORCID,Siu Michael⁵^ORCID,Patel Snahel⁵^ORCID,Modrusan Zora⁶,Liu Xingrong⁷,Rudhard York⁸,Baca Miriam²^ORCID,Gustafson Amy⁹^ORCID,Kaminker Josh¹⁰^ORCID,Carano Richard A. D.³^ORCID,Huang Eric J.⁴¹¹^ORCID,Foreman Oded²,Weimer Robby³,Scearce-Levie Kimberly¹,Lewcock Joseph W.¹^ORCID

Affiliation:

1. Department of Neuroscience, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.

2. Department of Pathology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.

3. Department of Biomedical Imaging, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.

4. Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA.

5. Department of Discovery Chemistry, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.

6. Department of Molecular Biology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.

7. Department of Drug Metabolism and Pharmacokinetics, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.

8. In Vitro Pharmacology, Evotec AG, Manfred Eigen Campus, 22419 Hamburg, Germany.

9. Department of Biochemical and Cellular Pharmacology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.

10. Department of Bioinformatics, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.

11. Pathology Service 113B, San Francisco Veterans Affairs Medical Center, San Francisco, CA 94121, USA.

Abstract

Blocking dual leucine zipper kinase slows disease progression in animal models of ALS and Alzheimer’s disease.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference50 articles.

1. Advances in treating amyotrophic lateral sclerosis: insights from pathophysiological studies

2. Alzheimer’s Disease: The Challenge of the Second Century

3. DLK induces developmental neuronal degeneration via selective regulation of proapoptotic JNK activity

4. Dual leucine zipper kinase is required for excitotoxicity-induced neuronal degeneration

5. DLK initiates a transcriptional program that couples apoptotic and regenerative responses to axonal injury

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