IVIG-mediated protection against necrotizing pneumonia caused by MRSA

Author:

Diep Binh An1,Le Vien T. M.1,Badiou Cedric23,Le Hoan N.1,Pinheiro Marcos Gabriel14,Duong Au H.1,Wang Xing1,Dip Etyene Castro1,Aguiar-Alves Fábio14,Basuino Li1,Marbach Helene1,Mai Thuy T.1,Sarda Marie N.5,Kajikawa Osamu6,Matute-Bello Gustavo6,Tkaczyk Christine7,Rasigade Jean-Philippe23,Sellman Bret R.7,Chambers Henry F.1,Lina Gerard23

Affiliation:

1. Division of HIV, Infectious Diseases, and Global Medicine, Department of Medicine, University of California, San Francisco, San Francisco, CA 94110, USA.

2. INSERM U1111, Université Lyon 1, CNRS UMR5308, ENS Lyon, Lyon, France.

3. Centre National de Référence des Staphylocoques, Hospices Civils de Lyon, Bron, France.

4. Pathology Program, Fluminense Federal University, Niterói, RJ, Brazil.

5. Laboratory of Immunology, Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, Lyon, France.

6. Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Washington School of Medicine, Seattle, WA 98109, USA.

7. Department of Infectious Diseases, MedImmune, LLC, Gaithersburg, MD 20878, USA.

Abstract

Human intravenous immunoglobulin contains specific antitoxin antibodies that protect against necrotizing pneumonia caused by MRSA in a rabbit model.

Funder

U.S. Public Health Service

NIH

UCSF Research Evaluation and Allocation Committee

AstraZeneca

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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