The druggable genome and support for target identification and validation in drug development-Reference-Cited by-同舟云学术

The druggable genome and support for target identification and validation in drug development

Published:2017-03-29 Issue:383 Volume:9 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Finan Chris¹²^ORCID,Gaulton Anna³^ORCID,Kruger Felix A.¹⁴,Lumbers R. Thomas¹²,Shah Tina¹²,Engmann Jorgen¹²^ORCID,Galver Luana⁵,Kelley Ryan⁵,Karlsson Anneli³^ORCID,Santos Rita³^ORCID,Overington John P.³⁴,Hingorani Aroon D.¹²,Casas Juan P.²

Affiliation:

1. Institute of Cardiovascular Science, Faculty of Population Health, University College London, London WC1E 6BT, U.K.

2. Farr Institute of Health Informatics, University College London, London WC1E 6BT, U.K.

3. European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, U.K.

4. BenevolentAI, 40 Churchway, London, U.K.

5. Illumina Inc., 5200 Illumina Way, San Diego, CA 92122, USA.

Abstract

The druggable genome and genome-wide association study data reveal new drug development and repurposing opportunities.

Funder

British Heart Foundation

Wellcome Trust

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference75 articles.

1. Lessons from 60 years of pharmaceutical innovation

2. How to improve R&D productivity: the pharmaceutical industry's grand challenge

3. Risk of Bias in Reports of In Vivo Research: A Focus for Improvement

4. Comparison of treatment effects between animal experiments and clinical trials: systematic review

5. Can Animal Models of Disease Reliably Inform Human Studies?

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