Imaging mitochondrial dynamics in human skin reveals depth-dependent hypoxia and malignant potential for diagnosis-Reference-Cited by-同舟云学术

Imaging mitochondrial dynamics in human skin reveals depth-dependent hypoxia and malignant potential for diagnosis

Published:2016-11-30 Issue:367 Volume:8 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Pouli Dimitra¹,Balu Mihaela²,Alonzo Carlo A.¹,Liu Zhiyi¹,Quinn Kyle P.¹³,Rius-Diaz Francisca⁴,Harris Ronald M.⁵,Kelly Kristen M.⁵,Tromberg Bruce J.²,Georgakoudi Irene¹

Affiliation:

1. Department of Biomedical Engineering, Tufts University, 4 Colby Street, Medford, MA 02155, USA.

2. Laser Microbeam and Medical Program, Beckman Laser Institute, University of California, Irvine, Irvine, CA 92612, USA.

3. Department of Biomedical Engineering, University of Arkansas, 120 John A. White Jr. Engineering Hall, Fayetteville, AR 72701, USA.

4. Department of Preventive Medicine and Public Health, Faculty of Medicine, University of Malaga, 32 Louis Pasteur Boulevard, 29071 Málaga, Spain.

5. Department of Dermatology, University of California, Irvine, 1 Medical Plaza Drive, Irvine, CA 92697, USA.

Abstract

In vivo, label-free evaluation of mitochondrial function in human skin epithelia noninvasively differentiates healthy from cancerous tissues.

Funder

American Cancer Society

NIH National Institute of Biomedical Imaging and Bioengineering Laser Microbeam and Medical Program

Alexander S. Onassis Public Benefit Foundation

Arnold and Mabel Beckman Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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5. Mitochondria in metabolic disease: Getting clues from proteomic studies

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