Pharmacological rescue of diabetic skeletal stem cell niches

Author:

Tevlin Ruth12,Seo Eun Young12,Marecic Owen12,McArdle Adrian12,Tong Xinming3,Zimdahl Bryan2,Malkovskiy Andrey4,Sinha Rahul2,Gulati Gunsagar2,Li Xiyan5,Wearda Taylor12,Morganti Rachel2,Lopez Michael2,Ransom Ryan C.2,Duldulao Christopher R.1,Rodrigues Melanie1,Nguyen Allison2,Januszyk Michael1,Maan Zeshaan1,Paik Kevin1,Yapa Kshemendra-Senarath1,Rajadas Jayakumar4,Wan Derrick C.1,Gurtner Geoffrey C.1,Snyder Michael5,Beachy Philip A.67,Yang Fan38,Goodman Stuart B.8,Weissman Irving L.29,Chan Charles K. F.129,Longaker Michael T.12

Affiliation:

1. Hagey Laboratory for Pediatric Regenerative Medicine and Department of Surgery, Stanford University, Palo Alto, CA 94305, USA.

2. Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Palo Alto, CA 94305, USA.

3. Department of Bioengineering, Stanford University, Palo Alto, CA 94305, USA.

4. Department of Biomaterials and Advanced Drug Delivery, Stanford University, Palo Alto, CA 94305, USA.

5. Department of Genetics, Stanford University, Palo Alto, CA 94305, USA.

6. Department of Biochemistry, Stanford University, Palo Alto, CA 94305, USA.

7. Howard Hughes Medical Institute, Stanford, CA 94305, USA.

8. Department of Orthopaedic Surgery, Stanford University, Palo Alto, CA 94305, USA.

9. Departments of Pathology and Developmental Biology, Stanford University, Palo Alto, CA 94305, USA.

Abstract

Local delivery of a missing growth factor to the skeletal stem cell niche restores bone healing in diabetic mice.

Funder

NIH

Thomas and Stacey Siebel Foundation

Prostate Cancer Foundation Young Investigator Award

National Institute on Aging Research Career Development Award

California Institute for Regenerative Medicine

Oak Foundation

Hagey Laboratory for Pediatric Regenerative Medicine

Gunn/Olivier Research Fund

CIRM

NSF CAREER

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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