A PTK7-targeted antibody-drug conjugate reduces tumor-initiating cells and induces sustained tumor regressions-Reference-Cited by-同舟云学术

A PTK7-targeted antibody-drug conjugate reduces tumor-initiating cells and induces sustained tumor regressions

Published:2017-01-11 Issue:372 Volume:9 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Damelin Marc¹,Bankovich Alexander²,Bernstein Jeffrey²,Lucas Justin¹,Chen Liang¹,Williams Samuel²,Park Albert²,Aguilar Jorge²,Ernstoff Elana¹,Charati Manoj¹,Dushin Russell³,Aujay Monette²,Lee Christina²,Ramoth Hanna²,Milton Milly²,Hampl Johannes²,Lazetic Sasha²,Pulito Virginia¹,Rosfjord Edward¹,Sun Yongliang³,King Lindsay³,Barletta Frank¹,Betts Alison³,Guffroy Magali¹,Falahatpisheh Hadi¹,O’Donnell Christopher J.³,Stull Robert²,Pysz Marybeth²,Escarpe Paul²,Liu David²,Foord Orit²,Gerber Hans Peter¹,Sapra Puja¹,Dylla Scott J.²

Affiliation:

1. Pfizer Worldwide Research and Development (R&D), 401 North Middletown Road, Pearl River, NY 10965, USA.

2. AbbVie Stemcentrx LLC, 450 East Jamie Court, South San Francisco, CA 94080, USA.

3. Pfizer Worldwide R&D, 445 Eastern Point Road, Groton, CT 06340, USA.

Abstract

PTK7 is a tumor-initiating cell antigen, which can be targeted with an antibody-drug conjugate to confer sustained tumor regressions.

Funder

Stemcentrx

Pfizer Worldwide R&D

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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