Combined targeting of BCL-2 and BCR-ABL tyrosine kinase eradicates chronic myeloid leukemia stem cells-Reference-Cited by-同舟云学术

Combined targeting of BCL-2 and BCR-ABL tyrosine kinase eradicates chronic myeloid leukemia stem cells

Published:2016-09-07 Issue:355 Volume:8 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Carter Bing Z.¹,Mak Po Yee¹,Mu Hong¹,Zhou Hongsheng¹,Mak Duncan H.¹,Schober Wendy¹,Leverson Joel D.²,Zhang Bin³,Bhatia Ravi⁴,Huang Xuelin⁵,Cortes Jorge⁶,Kantarjian Hagop⁶,Konopleva Marina¹,Andreeff Michael¹

Affiliation:

1. Section of Molecular Hematology and Therapy, Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

2. Department of Oncology Development, AbbVie Inc., North Chicago, IL 60064, USA.

3. Division of Hematopoietic Stem Cell and Leukemia Research, Beckman Research Institute, City of Hope Cancer Center, Duarte, CA 91010, USA.

4. Division of Hematology and Oncology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

5. Department of Biostatistics, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

6. Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

Abstract

Inhibition of BCL-2, MCL-1, and BCL-X L eradicates CML stem cells in a mouse model and primary blast crisis samples.

Funder

NIH

Paul and Mary Haas Chair in Genetics

AbbVie Inc.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference51 articles.

1. Dasatinib (BMS-354825) targets an earlier progenitor population than imatinib in primary CML but does not eliminate the quiescent fraction

2. Human chronic myeloid leukemia stem cells are insensitive to imatinib despite inhibition of BCR-ABL activity

3. Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro

4. Punish the parent not the progeny

5. Nonproliferating CML CD34+ progenitors are resistant to apoptosis induced by a wide range of proapoptotic stimuli

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