Microhemorrhage-associated tissue iron enhances the risk for Aspergillus fumigatus invasion in a mouse model of airway transplantation-Reference-Cited by-同舟云学术

Microhemorrhage-associated tissue iron enhances the risk for Aspergillus fumigatus invasion in a mouse model of airway transplantation

Published:2018-02-21 Issue:429 Volume:10 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Hsu Joe L.¹²^ORCID,Manouvakhova Olga V.²^ORCID,Clemons Karl V.³⁴^ORCID,Inayathullah Mohammed⁵^ORCID,Tu Allen B.²^ORCID,Sobel Raymond A.⁶⁷^ORCID,Tian Amy²^ORCID,Nazik Hasan³⁴⁸^ORCID,Pothineni Venkata R.⁵^ORCID,Pasupneti Shravani¹²^ORCID,Jiang Xinguo²,Dhillon Gundeep S.¹^ORCID,Bedi Harmeet¹^ORCID,Rajadas Jayakumar¹⁵,Haas Hubertus⁹^ORCID,Aurelian Laure¹⁰^ORCID,Stevens David A.³⁴,Nicolls Mark R.¹²^ORCID

Affiliation:

1. Division of Pulmonary and Critical Care Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.

2. Veterans Affairs Palo Alto Health Care System, Medical Service, Palo Alto, CA 94304, USA.

3. Infectious Diseases Research Laboratory, California Institute for Medical Research, San Jose, CA 95128, USA.

4. Division of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.

5. Biomaterials and Advanced Drug Delivery Laboratory, Cardiovascular Pharmacology Division, Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94304, USA.

6. Veterans Affairs Palo Alto Health Care System, Pathology and Laboratory Service, Palo Alto, CA 94304, USA.

7. Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.

8. Department of Medical Microbiology, Istanbul University School of Medicine, Istanbul, Turkey.

9. Division of Molecular Biology, Medical University Innsbruck, Innsbruck, Austria.

10. Department of Pharmacology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

Abstract

Increased ferric iron in allografts triggers a switch in the growth of the mold Aspergillus fumigatus from a colonizing to an invasive phenotype.

Funder

National Institutes of Health

The Parker Foundation

Austrian Science Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference66 articles.

1. The Registry of the International Society for Heart and Lung Transplantation: Thirty-second Official Adult Lung and Heart-Lung Transplantation Report—2015; Focus Theme: Early Graft Failure

2. Diagnosing invasive fungal disease in critically ill patients

3. Invasive Aspergillosis in Transplant Recipients

4. Epidemiology of fungal infections in solid organ transplant patients

5. Aspergillus Infections in Transplant Recipients

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