A conserved transcriptional response to intranasal Ebola virus exposure in nonhuman primates prior to onset of fever-Reference-Cited by-同舟云学术

A conserved transcriptional response to intranasal Ebola virus exposure in nonhuman primates prior to onset of fever

Published:2018-03-28 Issue:434 Volume:10 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Speranza Emily¹^ORCID,Bixler Sandra L.²^ORCID,Altamura Louis A.³^ORCID,Arnold Catherine E.⁴^ORCID,Pratt William D.⁵,Taylor-Howell Cheryl³^ORCID,Burrows Christina³^ORCID,Aguilar William³^ORCID,Rossi Franco⁵,Shamblin Joshua D.⁵,Wollen Suzanne E.⁵^ORCID,Zelko Justine M.⁵^ORCID,Minogue Timothy³,Nagle Elyse⁴,Palacios Gustavo⁴^ORCID,Goff Arthur J.⁵^ORCID,Connor John H.¹^ORCID

Affiliation:

1. Department of Microbiology, Bioinformatics Program, National Emerging Infectious Diseases Laboratories, Boston University, Boston, MA 02118, USA.

2. Molecular and Translational Sciences Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA.

3. Diagnostic Systems Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA.

4. Center for Genome Sciences, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA.

5. Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA.

Abstract

An animal model of Ebola virus infection with variable disease onset identifies host markers of infection that precede symptoms by 4 days.

Funder

National Science Foundation

National Institute of Allergy and Infectious Diseases

Defense Threat Reduction Agency

Intelligence Advanced Research Projects Activity

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference46 articles.

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2. Center for Disease Control (CDC) 2014 Ebola Outbreak in West Africa - Case Counts Ebola Hemorrhagic Fever CDC; www.cdc.gov/vhf/ebola/outbreaks/2014-west-africa/case-counts.html.

3. Animal models for Ebola and Marburg virus infections

4. Disease modeling for Ebola and Marburg viruses

5. Lethal experimental infections of rhesus monkeys by aerosolized Ebola virus;Johnson E.;Int. J. Exp. Pathol.,1995

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