Discovery of short-course antiwolbachial quinazolines for elimination of filarial worm infections-Reference-Cited by-同舟云学术

Discovery of short-course antiwolbachial quinazolines for elimination of filarial worm infections

Published:2019-05-08 Issue:491 Volume:11 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Bakowski Malina A.¹^ORCID,Shiroodi Roohollah Kazem¹,Liu Renhe²,Olejniczak Jason¹^ORCID,Yang Baiyuan¹,Gagaring Kerstin¹^ORCID,Guo Hui¹^ORCID,White Pamela M.³^ORCID,Chappell Laura³^ORCID,Debec Alain⁴,Landmann Frédéric⁵,Dubben Bettina⁶,Lenz Franziska⁶^ORCID,Struever Dominique⁶^ORCID,Ehrens Alexandra⁶^ORCID,Frohberger Stefan J.⁶,Sjoberg Hanna⁷^ORCID,Pionnier Nicolas⁷^ORCID,Murphy Emma⁷^ORCID,Archer John⁷,Steven Andrew⁷,Chunda Valerine C.⁸⁹^ORCID,Fombad Fanny F.⁸⁹^ORCID,Chounna Patrick W.⁸⁹^ORCID,Njouendou Abdel J.⁸⁹,Metuge Haelly M.⁸^ORCID,Ndzeshang Bertrand L.⁸⁹,Gandjui Narcisse V.⁸⁹,Akumtoh Desmond N.⁸⁹,Kwenti Tayong D. B.⁸⁹^ORCID,Woods Ashley K.¹,Joseph Sean B.¹^ORCID,Hull Mitchell V.¹^ORCID,Xiong Wen²^ORCID,Kuhen Kelli L.¹,Taylor Mark J.⁷^ORCID,Wanji Samuel⁸⁹,Turner Joseph D.⁷^ORCID,Hübner Marc P.⁶^ORCID,Hoerauf Achim⁶^ORCID,Chatterjee Arnab K.¹,Roland Jason¹,Tremblay Matt S.¹,Schultz Peter G.¹,Sullivan William³,Chu Xin-Jie²,Petrassi H. Michael¹,McNamara Case W.¹^ORCID

Affiliation:

1. Calibr at Scripps Research, La Jolla, CA 92037, USA.

2. Global Health Drug Discovery Institute (GHDDI), Beijing, China.

3. University of California Santa Cruz, Santa Cruz, CA 95064, USA.

4. Jacques Monod Institute, University Paris Diderot/CNRS, 75013 Paris, France.

5. CRBM, University of Montpellier, CNRS, Montpellier, France.

6. Institute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn, Germany.

7. Research Centre for Drugs and Diagnostics, Department of Parasitology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK.

8. Research Foundation in Tropical Diseases and the Environment, Buea, Cameroon.

9. Parasite and Vector Biology Research Unit, Department of Microbiology and Parasitology, Faculty of Science, University of Buea, Buea, Cameroon.

Abstract

This study identifies oral, highly efficacious antiwolbachial compounds to cure filarial infections in mice.

Funder

Bill and Melinda Gates Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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