Strong T H 1-biased CD4 T cell responses are associated with diminished SIV vaccine efficacy-Reference-Cited by-同舟云学术

Strong T H 1-biased CD4 T cell responses are associated with diminished SIV vaccine efficacy

Published:2019-11-20 Issue:519 Volume:11 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Chamcha Venkateswarlu¹²^ORCID,Reddy Pradeep B. J.¹²^ORCID,Kannanganat Sunil¹²^ORCID,Wilkins Courtney³,Gangadhara Sailaja¹²^ORCID,Velu Vijayakumar¹²^ORCID,Green Richard³,Law G. Lynn³^ORCID,Chang Jean³^ORCID,Bowen James R.¹⁴,Kozlowski Pamela A.⁵,Lifton Michelle⁶,Santra Sampa⁶,Legere Traci¹^ORCID,Chea Lynette S.¹²,Chennareddi Lakshmi¹²,Yu Tianwei⁷,Suthar Mehul S.¹⁴^ORCID,Silvestri Guido¹⁸^ORCID,Derdeyn Cynthia A.¹⁸,Gale Michael³^ORCID,Villinger Francois¹⁸,Hunter Eric¹⁸^ORCID,Amara Rama Rao¹²^ORCID

Affiliation:

1. Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.

2. Department of Microbiology and Immunology, Emory School of Medicine, Emory University, Atlanta, GA 30322, USA.

3. Department of Immunology, Center for Innate Immunity and Immune Disease, University of Washington School of Medicine, Seattle, WA 981909, USA.

4. Division of Infectious Diseases, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA.

5. Department of Microbiology, Immunology and Parasitology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA.

6. Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.

7. Department of Biostatistics and Bioinformatics, Emory University, Atlanta, GA 30322, USA.

8. Department of Pathology, Emory School of Medicine, Emory University, Atlanta, GA 30322, USA.

Abstract

Vaccine-induced IFNγ + CD4 T cells migrate to and persist in mucosal tissue and negatively associate with protection against SIV.

Funder

National Institutes of Health

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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