A pannexin 1 channelopathy causes human oocyte death

Author:

Sang Qing1ORCID,Zhang Zhihua1ORCID,Shi Juanzi2ORCID,Sun Xiaoxi3ORCID,Li Bin4ORCID,Yan Zheng4ORCID,Xue Songguo5,Ai Ai4,Lyu Qifeng4,Li Wei6,Zhang Jilin6,Wu Ling4,Mao Xiaoyan4,Chen Biaobang1,Mu Jian1,Li Qiaoli1,Du Jing7,Sun Qiang6,Jin Li1,He Lin8,Zhu Shujia6,Kuang Yanping4ORCID,Wang Lei19ORCID

Affiliation:

1. Zhongshan Hospital, State Key Laboratory of Genetic Engineering, Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China.

2. Reproductive Medicine Center, Shaanxi Maternal and Child Care Service Center, Shaanxi 710069, China.

3. Shanghai Ji Ai Genetics and IVF Institute, Obstetrics and Gynecology Hospital, Fudan University, Shanghai 200011, China.

4. Reproductive Medicine Center, Shanghai Ninth Hospital, Shanghai Jiao Tong University, Shanghai 200011, China.

5. Reproductive Medicine Center, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai 2000120, China.

6. Institute of Neuroscience, Key Laboratory of Primate Neurobiology, CAS Center for Excellence in Brain Science, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.

7. Shanghai Institute of Planned Parenthood Research, Shanghai 200011, China.

8. Bio-X Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai 200030, China.

9. Shanghai Center for Women and Children’s Health, Shanghai 200062, China.

Abstract

Inherited dominant mutations in PANX1 cause female infertility characterized by oocyte death.

Funder

NSFC

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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