The autophagy-activating kinase ULK1 mediates clearance of free α-globin in β-thalassemia-Reference-Cited by-同舟云学术

The autophagy-activating kinase ULK1 mediates clearance of free α-globin in β-thalassemia

Published:2019-08-21 Issue:506 Volume:11 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Lechauve Christophe¹^ORCID,Keith Julia¹,Khandros Eugene²^ORCID,Fowler Stephanie¹,Mayberry Kalin¹,Freiwan Abdullah¹,Thom Christopher S.³^ORCID,Delbini Paola⁴⁵,Romero Emilio Boada⁶^ORCID,Zhang Jingjing¹,Motta Irene⁴⁵^ORCID,Tillman Heather⁷^ORCID,Cappellini M. Domenica⁴⁵,Kundu Mondira⁷^ORCID,Weiss Mitchell J.¹^ORCID

Affiliation:

1. Department of Hematology, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA.

2. Department of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.

3. Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.

4. Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy.

5. Department of Clinical Sciences and Community Health, University of Milan, 20122 Milan, Italy.

6. Department of Immunology, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA.

7. Departments of Pathology and Cell and Molecular Biology, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA.

Abstract

Rapamycin alleviates β-thalassemia by stimulating ULK1-dependent clearance of toxic free α-globin.

Funder

National Heart, Lung, and Blood Institute

National Institute of Diabetes and Digestive and Kidney Diseases

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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4. Oxidative red blood cell membrane injury in the pathophysiology of severe mouse beta-thalassemia

5. E. Rachmilewitz S. Schrier in Disorders of Hemoglobin: Genetics Pathophysiology and Clinical Management M. H. Steinberg B. G. Forget R. Higgs R. L. Nagel Eds. (Cambridge Univ. Press ed. 1 2001).

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