ATRAID regulates the action of nitrogen-containing bisphosphonates on bone

Author:

Surface Lauren E.1ORCID,Burrow Damon T.2ORCID,Li Jinmei2ORCID,Park Jiwoong2ORCID,Kumar Sandeep2ORCID,Lyu Cheng2ORCID,Song Niki2ORCID,Yu Zhou1,Rajagopal Abbhirami3,Bae Yangjin3ORCID,Lee Brendan H.3ORCID,Mumm Steven24ORCID,Gu Charles C.5ORCID,Baker Jonathan C.6ORCID,Mohseni Mahshid2,Sum Melissa7,Huskey Margaret2,Duan Shenghui2ORCID,Bijanki Vinieth N.4ORCID,Civitelli Roberto2ORCID,Gardner Michael J.8,McAndrew Chris M.9ORCID,Ricci William M.10,Gurnett Christina A.911ORCID,Diemer Kathryn2ORCID,Wan Fei12ORCID,Costantino Christina L.13ORCID,Shannon Kristen M.14,Raje Noopur14,Dodson Thomas B.15ORCID,Haber Daniel A.1416ORCID,Carette Jan E.17,Varadarajan Malini18ORCID,Brummelkamp Thijn R.192021ORCID,Birsoy Kivanc22ORCID,Sabatini David M.16232425ORCID,Haller Gabe1126ORCID,Peterson Timothy R.22728ORCID

Affiliation:

1. Department of Molecular and Cellular Biology, Department of Chemistry and Chemical Biology, Faculty of Arts and Sciences Center for Systems Biology, Harvard University, Cambridge, MA 02138, USA.

2. Division of Bone and Mineral Diseases, Department of Medicine, Washington University School of Medicine, BJC Institute of Health, 425 S. Euclid Ave., St. Louis, MO 63110, USA.

3. Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.

4. Center for Metabolic Bone Disease and Molecular Research, Shriners Hospital for Children, St. Louis, MO 63110, USA.

5. Division of Biostatistics, Washington University School of Medicine, 660 S. Euclid Ave., Campus Box 8067, St. Louis, MO 63110, USA.

6. Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 S. Kingshighway Blvd., St. Louis, MO 63110, USA.

7. Division of Endocrinology, Diabetes and Metabolism, NYU Langone Health, 530 1st Ave., Schwartz 5E., New York, NY 10016, USA.

8. Department of Orthopedic Surgery, Stanford University, 450 Broadway Street, Redwood City, CA 94063, USA.

9. Department of Orthopedic Surgery, Washington University School of Medicine, 4938 Parkview Place, St. Louis, MO 63110, USA.

10. Hospital for Special Surgery Main Campus–Belaire Building, 525 East 71st Street 2nd Floor, New York, NY 10021, USA.

11. Department of Neurology, Washington University School of Medicine, Campus Box 8111, 660 S. Euclid Ave., St. Louis, MO 63110, USA.

12. Department of Surgery, Washington University School of Medicine, Campus Box 8109, 4590 Children’s Place, Suite 9600, St. Louis, MO 63110, USA.

13. Massachusetts General Hospital Cancer Center and Department of Surgery, Harvard Medical School, Boston, MA 02114, USA.

14. Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA 02114, USA.

15. Department of Oral and Maxillofacial Surgery, Massachusetts General Hospital and Harvard School of Dental Medicine, Boston, MA 02114, USA.

16. Howard Hughes Medical Institute (HHMI), Chevy Chase, MD 20815, USA.

17. Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.

18. Oncology Disease Area, Novartis Institutes for BioMedical Research, Cambridge, CA 02140, USA.

19. Oncode Institute, Division of Biochemistry, The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX Amsterdam, Netherlands.

20. CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria.

21. Cancer Genomics Center, Plesmanlaan 121, 1066CX Amsterdam, Netherlands.

22. The Rockefeller University, 1230 York Ave., New York, NY 10065, USA.

23. Whitehead Institute, 9 Cambridge Center, Cambridge, MA 02139, USA.

24. Department of Biology, Massachusetts Institute of Technology (MIT), 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

25. David H. Koch Center for Integrative Cancer Research at MIT, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

26. Department of Neurosurgery, Washington University School of Medicine, Campus Box 8057, 660 S. Euclid Ave., St. Louis, MO 63110, USA.

27. Department of Genetics, Washington University School of Medicine, 4515 McKinley Ave. Campus Box 8232, St. Louis, MO 63110, USA.

28. Institute for Public Health, Washington University School of Medicine, 600 S. Taylor Suite 2400, Campus Box 8217, St. Louis, MO 63110, USA.

Abstract

ATRAID is essential for responses to the commonly prescribed osteoporosis drugs nitrogen-containing bisphosphonates.

Funder

National Institutes of Health

U.S. Department of Defense

Howard Hughes Medical Institute

W.M. Keck Foundation

LAM Foundation

National Institute of Arthritis and Musculoskeletal and Skin Diseases

National Institute on Aging

Jane Coffin Childs Memorial Fund for Medical Research

National Institute of Diabetes and Digestive and Kidney Diseases

National Cancer Institute

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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