Dendritic cells dictate responses to PD-L1 blockade cancer immunotherapy

Author:

Mayoux Maud1ORCID,Roller Andreas2,Pulko Vesna1,Sammicheli Stefano1ORCID,Chen Stanford1,Sum Eva1ORCID,Jost Christian1ORCID,Fransen Marieke F.3ORCID,Buser Regula B.1,Kowanetz Marcin4,Rommel Karolin1,Matos Ines1ORCID,Colombetti Sara1,Belousov Anton5ORCID,Karanikas Vaios1,Ossendorp Ferry3,Hegde Priti S.4,Chen Daniel S.6ORCID,Umana Pablo1ORCID,Perro Mario1ORCID,Klein Christian1ORCID,Xu Wei1ORCID

Affiliation:

1. Cancer Immunotherapy Discovery, Pharmaceutical Research and Early Development, Roche Innovation Center Zurich, Schlieren 8952, Switzerland.

2. Pharmaceutical Sciences, Biomarkers, Bioinformatics and Omics & Pathology, Pharmaceutical Research and Early Development, Roche Innovation Center Basel, Basel 4070, Switzerland.

3. Department of Immunohematology and Bloodtransfusion, Leiden University Medical Center, Leiden 2333, Netherlands.

4. Oncology Biomarker Development, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.

5. Pharmaceutical Sciences, Biomarkers, Bioinformatics and Omics, Pharmaceutical Research and Early Development, Roche Innovation Center Munich, Penzberg 82377, Germany.

6. Product Development, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.

Abstract

DCs are critical cellular targets of PD-L1 blockade in cancer treatment.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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