Adipose tissue–derived WNT5A regulates vascular redox signaling in obesity via USP17/RAC1-mediated activation of NADPH oxidases-Reference-Cited by-同舟云学术

Adipose tissue–derived WNT5A regulates vascular redox signaling in obesity via USP17/RAC1-mediated activation of NADPH oxidases

Published:2019-09-18 Issue:510 Volume:11 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Akoumianakis Ioannis¹^ORCID,Sanna Fabio¹^ORCID,Margaritis Marios¹^ORCID,Badi Ileana¹^ORCID,Akawi Nadia¹^ORCID,Herdman Laura¹^ORCID,Coutinho Patricia¹^ORCID,Fagan Harry¹,Antonopoulos Alexios S.¹^ORCID,Oikonomou Evangelos K.¹^ORCID,Thomas Sheena¹^ORCID,Chiu Amy P.¹,Chuaiphichai Surawee¹,Kotanidis Christos P.¹^ORCID,Christodoulides Constantinos²,Petrou Mario³^ORCID,Krasopoulos George³^ORCID,Sayeed Rana³^ORCID,Lv Lei¹,Hale Ashley¹,Naeimi Kararoudi Meisam¹,McNeill Eileen¹,Douglas Gillian¹,George Sarah⁴^ORCID,Tousoulis Dimitris⁵^ORCID,Channon Keith M.¹^ORCID,Antoniades Charalambos¹^ORCID

Affiliation:

1. Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK.

2. Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, OX3 7LE, UK.

3. Department of Cardiothoracic Surgery, Oxford University Hospitals NHS Trust, Oxford, OX3 9DU, UK.

4. Bristol Medical School, University of Bristol, Research Floor Level 7, Bristol Royal Infirmary, Bristol BS2 8HW, UK.

5. Cardiology Department, Athens University Medical School, Athens 115 27, Greece.

Abstract

Adipose-secreted WNT5A triggers vascular disease in obesity, activating vascular smooth muscle cell migration by an NADPH oxidase–dependent mechanism.

Funder

Wellcome Trust

British Heart Foundation

Novo Nordisk UK Research Foundation

European Commission

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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