Inhaled corticosteroid suppression of cathelicidin drives dysbiosis and bacterial infection in chronic obstructive pulmonary disease-Reference-Cited by-同舟云学术

Inhaled corticosteroid suppression of cathelicidin drives dysbiosis and bacterial infection in chronic obstructive pulmonary disease

Published:2019-08-28 Issue:507 Volume:11 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Singanayagam Aran¹^ORCID,Glanville Nicholas¹^ORCID,Cuthbertson Leah²,Bartlett Nathan W.¹³^ORCID,Finney Lydia J.²^ORCID,Turek Elena²,Bakhsoliani Eteri¹^ORCID,Calderazzo Maria Adelaide¹,Trujillo-Torralbo Maria-Belen¹,Footitt Joseph¹,James Phillip L.²,Fenwick Peter²,Kemp Samuel V.⁴,Clarke Thomas B.⁵,Wedzicha Jadwiga A.²,Edwards Michael R.¹,Moffatt Miriam²^ORCID,Cookson William O.²^ORCID,Mallia Patrick¹^ORCID,Johnston Sebastian L.¹^ORCID

Affiliation:

1. National Heart and Lung Institute, St Mary’s Campus, Imperial College London, London W2 1PG, UK.

2. National Heart and Lung Institute, Brompton Campus, Imperial College London, London SW3 6LY, UK.

3. Faculty of Health and Medicine and Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute and University of Newcastle, Newcastle, NSW 2305, Australia.

4. Royal Brompton Hospital, Fulham Road, London SW2 6NP, UK.

5. MRC Centre for Molecular Bacteriology and Infection, Department of Medicine, Imperial College London, London SW7 2AZ, UK.

Abstract

Inhaled corticosteroids promote bacterial infection in chronic obstructive pulmonary disease by suppressing the antimicrobial peptide cathelicidin.

Funder

Wellcome Trust

British Lung Foundation

British Medical Association

NIHR

Publisher

American Association for the Advancement of Science (AAAS)

Subject