LRRK2 inhibitors induce reversible changes in nonhuman primate lungs without measurable pulmonary deficits-Reference-Cited by-同舟云学术

LRRK2 inhibitors induce reversible changes in nonhuman primate lungs without measurable pulmonary deficits

Published:2020-04-22 Issue:540 Volume:12 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Baptista Marco A. S.¹^ORCID,Merchant Kalpana²,Barrett Ted³^ORCID,Bhargava Sakshi⁴^ORCID,Bryce Dianne K.⁵^ORCID,Ellis J. Michael⁵^ORCID,Estrada Anthony A.⁶,Fell Matthew J.⁵,Fiske Brian K.¹^ORCID,Fuji Reina N.⁶^ORCID,Galatsis Paul⁴^ORCID,Henry Anastasia G.⁷^ORCID,Hill Sue⁵^ORCID,Hirst Warren⁴,Houle Christopher⁴^ORCID,Kennedy Matthew E.⁵^ORCID,Liu Xingrong⁶^ORCID,Maddess Matthew L.⁵^ORCID,Markgraf Carrie⁵,Mei Hong⁵^ORCID,Meier William A.⁸,Needle Elie⁴,Ploch Stephen⁸^ORCID,Royer Christopher³^ORCID,Rudolph Karin³^ORCID,Sharma Alok K.⁸,Stepan Antonia⁴,Steyn Stefan⁴^ORCID,Trost Craig⁸,Yin Zhizhang⁵,Yu Hongshi⁵,Wang Xiang⁷^ORCID,Sherer Todd B.¹

Affiliation:

1. The Michael J. Fox Foundation for Parkinson’s Research, Grand Central Station, P.O. Box 4777, New York, NY 10001, USA.

2. Northwestern University School of Medicine, Chicago, IL 60611, USA.

3. Lovelace Respiratory Research Institute, Albuquerque, NM 87108, USA.

4. Pfizer Inc., Neuroscience Research Unit, Cambridge, MA 02139, USA.

5. Merck Research Laboratories, Early Discovery Neuroscience, Boston, MA 02115, USA.

6. Genentech, Inc., South San Francisco, CA 94080, USA.

7. Denali Therapeutics, South San Francisco, CA 94080, USA.

8. Covance Laboratories, Inc., Madison, WI 53704, USA.

Abstract

Morphological changes in the lungs of macaques induced by several different LRRK2 inhibitors are reversible and do not lead to lung deficits.

Funder