Cotrimoxazole reduces systemic inflammation in HIV infection by altering the gut microbiome and immune activation-Reference-Cited by-同舟云学术

Cotrimoxazole reduces systemic inflammation in HIV infection by altering the gut microbiome and immune activation

Published:2019-04-03 Issue:486 Volume:11 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Bourke Claire D.¹^ORCID,Gough Ethan K.²^ORCID,Pimundu Godfrey³,Shonhai Annie⁴^ORCID,Berejena Chipo⁴,Terry Louise⁵,Baumard Lucas¹^ORCID,Choudhry Naheed¹^ORCID,Karmali Yusuf¹,Bwakura-Dangarembizi Mutsa⁴^ORCID,Musiime Victor³⁶^ORCID,Lutaakome Joseph⁷,Kekitiinwa Adeodata⁸,Mutasa Kuda⁹,Szubert Alexander J.¹⁰^ORCID,Spyer Moira J.¹⁰^ORCID,Deayton Jane R.¹⁵,Glass Magdalena²,Geum Hyun Min²,Pardieu Claire¹^ORCID,Gibb Diana M.¹⁰^ORCID,Klein Nigel¹¹^ORCID,Edens Thaddeus J.¹²,Walker A. Sarah¹⁰,Manges Amee R.²^ORCID,Prendergast Andrew J.¹⁹¹⁰

Affiliation:

1. Blizard Institute, Queen Mary University of London, London E1 2AT, UK.

2. School of Population and Public Health, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.

3. Joint Clinical Research Centre, Kampala, Uganda.

4. College of Health Sciences, University of Zimbabwe, Harare, Zimbabwe.

5. Royal London Hospital, Barts Health NHS Trust, London E1 1BB, UK.

6. College of Health Sciences, Department of Paediatrics and Child Health, Makerere University, Kampala, Uganda.

7. Uganda Virus Research Institute/MRC Uganda Research Unit on AIDS, Entebbe, Uganda.

8. Baylor College of Medicine Children’s Foundation—Uganda, Mulago Hospital, Kampala, Uganda.

9. Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe.

10. MRC Clinical Trials Unit at University College London, London WC1V 6LJ, UK.

11. UCL Great Ormond Street Institute of Child Health, London WC1N 1EH, UK.

12. Devil’s Staircase Consulting, West Vancouver, British Columbia V7T 1V7, Canada.

Abstract

Cotrimoxazole reduces systemic and intestinal inflammation in HIV infection by suppressing gut-resident Streptococci and immune cell activation.

Funder

Wellcome Trust

Canadian Institutes of Health Research

Medical Research Council

Department for International Development, UK Government

The Wellcome Trust and The Royal Society

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference68 articles.

1. UNAIDS Fact sheet - Latest global and regional statistics on the status of the AIDS epidemic - July 2018. (2018).

2. The expanding role of co-trimoxazole in developing countries

3. Daily co-trimoxazole prophylaxis in severely immunosuppressed HIV-infected adults in Africa started on combination antiretroviral therapy: an observational analysis of the DART cohort

4. WHO Guidelines on post-exposure prophylaxis for HIV and the use of co-trimoxazole prophylaxis for HIV-related infections among adults adolescents and children: Recommendations for a public health approach - December 2014 supplement to the 2013 consolidated ARV guidelines (WHO Press 2014) pp. 49.

5. Baseline Inflammatory Biomarkers Identify Subgroups of HIV-Infected African Children With Differing Responses to Antiretroviral Therapy

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