A multimodality test to guide the management of patients with a pancreatic cyst

Author:

Springer Simeon12ORCID,Masica David L.234,Dal Molin Marco25ORCID,Douville Christopher1234ORCID,Thoburn Christopher J.12ORCID,Afsari Bahman26ORCID,Li Lu12ORCID,Cohen Joshua D.123ORCID,Thompson Elizabeth25ORCID,Allen Peter J.7,Klimstra David S.8,Schattner Mark A.9,Schmidt C. Max10ORCID,Yip-Schneider Michele10ORCID,Simpson Rachel E.10,Fernandez-Del Castillo Carlos11,Mino-Kenudson Mari12ORCID,Brugge William13ORCID,Brand Randall E.14ORCID,Singhi Aatur D.15,Scarpa Aldo1617ORCID,Lawlor Rita1617ORCID,Salvia Roberto18ORCID,Zamboni Giuseppe19ORCID,Hong Seung-Mo20ORCID,Hwang Dae Wook21ORCID,Jang Jin-Young22ORCID,Kwon Wooil22ORCID,Swan Niall23ORCID,Geoghegan Justin24ORCID,Falconi Massimo25,Crippa Stefano25,Doglioni Claudio26ORCID,Paulino Jorge27ORCID,Schulick Richard D.28ORCID,Edil Barish H.28ORCID,Park Walter29,Yachida Shinichi30,Hijioka Susumu31ORCID,van Hooft Jeanin32,He Jin33,Weiss Matthew J.33,Burkhart Richard33,Makary Martin33,Canto Marcia I.34,Goggins Michael G.25634ORCID,Ptak Janine12ORCID,Dobbyn Lisa12ORCID,Schaefer Joy12ORCID,Sillman Natalie12ORCID,Popoli Maria12ORCID,Klein Alison P.126ORCID,Tomasetti Cristian235ORCID,Karchin Rachel2346ORCID,Papadopoulos Nickolas12ORCID,Kinzler Kenneth W.12ORCID,Vogelstein Bert12ORCID,Wolfgang Christopher L.2633ORCID,Hruban Ralph H.1256ORCID,Lennon Anne Marie1263334ORCID

Affiliation:

1. Ludwig Center and Howard Hughes Medical Institute at the Sidney Kimmel Cancer Center, Johns Hopkins University, Baltimore, MD 21287, USA.

2. Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University, Baltimore, MD 21287, USA.

3. Department of Biomedical Engineering, Johns Hopkins Medical Institutions, Johns Hopkins University, Baltimore, MD 21287, USA.

4. Institute for Computational Medicine, Johns Hopkins University, Baltimore, MD 21287, USA.

5. Department of Pathology, Johns Hopkins University, Baltimore, MD 21287, USA.

6. Department of Oncology, Johns Hopkins University, Baltimore, MD 21287, USA.

7. Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

8. Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

9. Department of Gastroenterology, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

10. Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

11. Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA

12. Department of Histopathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

13. Department of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

14. Department of Medicine, University of Pittsburgh, Pittsburgh PA 15213, USA.

15. Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15213, USA.

16. ARC-Net Research Centre, University and Hospital Trust of Verona, Verona 37134, Italy.

17. Department of Pathology and Diagnostics, University and Hospital Trust of Verona, Verona 37134, Italy.

18. General and Pancreatic Surgery, Pancreas Institute, University and Hospital Trust of Verona, Verona 37134, Italy.

19. Department of Pathology, Ospedale Sacro Cuore-Don Calabria, Negrar 37024, Italy,

20. Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, South Korea.

21. Hepatobiliary and Pancreas Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, South Korea.

22. Department of Surgery and Cancer Research Institute, Seoul National University College of Medicine, Seoul 03080, South Korea.

23. Department of Histopathology, St. Vincent’s University Hospital, Dublin D04 T6F4, Ireland.

24. Department of Surgery, St. Vincent’s University Hospital, Dublin D04 T6F4, Ireland.

25. Division of Pancreatic Surgery, Department of Surgery, IRCCS San Raffaele Scientific Institute, Milan 20132, Italy.

26. Department of Pathology, IRCCS San Raffaele Scientific Institute, Milan 20132, Italy.

27. Department of Surgery, Centro Hepatobiliopancreático e Transplantação, Hospital Curry Cabral, Lisbon 1050-099, Portugal.

28. Department of Surgery, University of Colorado, Aurora, CO 80045, USA.

29. Department of Medicine, Stanford University Medical Center, Palo Alto, CA 94304, USA.

30. Department of Hepatobiliary and Pancreatic Surgery, Pathology and Cancer Genomics, National Cancer Center Hospital and National Cancer Center Research Institute, Tokyo 104-0045, Japan.

31. Department of Gastroenterology, Aichi Cancer Center Hospital, Nagoya 464-8681, Japan.

32. Department of Gastroenterology and Hepatology, Amsterdam Medical Center, Amsterdam 1017 ZX, Netherlands.

33. Department of Surgery, Johns Hopkins University, Baltimore, MD 21287, USA.

34. Department of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA.

35. Department of Biostatistics and Bioinformatics, Johns Hopkins University, Baltimore, MD 21287, USA.

Abstract

Molecular and clinical markers outperform current clinical and imaging criteria for the diagnosis and management of patients with pancreatic cysts.

Funder

National Institutes of Health

Lustgarten Foundation

The Sol Goldman Center for Pancreatic Cancer Research

Susan Wojcicki and Dennis Troper

The Virginia and D.K. Ludwig Fund

The Michael Rolfe Pancreatic Cancer Research Foundation

The John Templeton Foundation

The Benjamin Baker Scholarship

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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