A bifunctional nociceptin and mu opioid receptor agonist is analgesic without opioid side effects in nonhuman primates-Reference-Cited by-同舟云学术

A bifunctional nociceptin and mu opioid receptor agonist is analgesic without opioid side effects in nonhuman primates

Published:2018-08-29 Issue:456 Volume:10 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Ding Huiping¹^ORCID,Kiguchi Norikazu¹²^ORCID,Yasuda Dennis³,Daga Pankaj R.³^ORCID,Polgar Willma E.³,Lu James J.³,Czoty Paul W.¹^ORCID,Kishioka Shiroh²,Zaveri Nurulain T.³^ORCID,Ko Mei-Chuan¹⁴^ORCID

Affiliation:

1. Department of Physiology and Pharmacology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.

2. Department of Pharmacology, Wakayama Medical University, Wakayama, Japan.

3. Astraea Therapeutics, Mountain View, CA 94043, USA.

4. W.G. Hefner Veterans Affairs Medical Center, Salisbury, NC 28144, USA.

Abstract

The small-molecule AT-121 is an agonist of nociceptin and mu opioid peptide receptors and mediates analgesia without opioid-associated side effects in nonhuman primates.

Funder

U.S. Department of Defense

National Institute on Drug Abuse

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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