KHS101 disrupts energy metabolism in human glioblastoma cells and reduces tumor growth in mice-Reference-Cited by-同舟云学术

KHS101 disrupts energy metabolism in human glioblastoma cells and reduces tumor growth in mice

Published:2018-08-15 Issue:454 Volume:10 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Polson Euan S.¹^ORCID,Kuchler Verena B.¹^ORCID,Abbosh Christopher¹,Ross Edith M.²^ORCID,Mathew Ryan K.¹³^ORCID,Beard Hester A.⁴^ORCID,da Silva Bárbara¹,Holding Andrew N.²^ORCID,Ballereau Stephane²^ORCID,Chuntharpursat-Bon Eulashini¹^ORCID,Williams Jennifer¹,Griffiths Hollie B.S.⁵,Shao Hao⁶^ORCID,Patel Anjana¹^ORCID,Davies Adam J.¹^ORCID,Droop Alastair¹^ORCID,Chumas Paul³,Short Susan C.¹^ORCID,Lorger Mihaela¹,Gestwicki Jason E.⁶,Roberts Lee D.¹^ORCID,Bon Robin S.¹⁴^ORCID,Allison Simon J.⁵^ORCID,Zhu Shoutian⁷,Markowetz Florian²^ORCID,Wurdak Heiko¹^ORCID

Affiliation:

1. School of Medicine, University of Leeds, Leeds LS2 9JT, UK.

2. Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, UK.

3. Department of Neurosurgery, Leeds General Infirmary, Leeds LS1 3EX, UK.

4. School of Chemistry, University of Leeds, Leeds LS2 9JT, UK.

5. School of Applied Sciences, University of Huddersfield, Huddersfield HD1 3DH, UK.

6. Department of Pharmaceutical Chemistry and the Institute for Neurodegenerative Disease, University of California, San Francisco, 675 Nelson Rising Lane, San Francisco, CA 94158, USA.

7. California Institute for Biomedical Research, 11119 North Torrey Pines Road, Suite 100, La Jolla, CA 92037, USA.

Abstract

Modulation of energy metabolism with the small-molecule KHS101 promoted tumor-selective death of human glioblastoma cells and reduced tumor growth in mice.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference60 articles.

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2. Emerging treatment strategies for glioblastoma multiforme

3. A novel small molecule that selectively inhibits glioblastoma cells expressing EGFRvIII

4. Inhibition of BET Bromodomain Targets Genetically Diverse Glioblastoma

5. Identification and Characterization of a Small-Molecule Inhibitor of Wnt Signaling in Glioblastoma Cells

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