Development of a stress response therapy targeting aggressive prostate cancer-Reference-Cited by-同舟云学术

Development of a stress response therapy targeting aggressive prostate cancer

Published:2018-05-02 Issue:439 Volume:10 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Nguyen Hao G.¹,Conn Crystal S.¹^ORCID,Kye Yae¹^ORCID,Xue Lingru¹^ORCID,Forester Craig M.²^ORCID,Cowan Janet E.¹^ORCID,Hsieh Andrew C.¹^ORCID,Cunningham John T.¹^ORCID,Truillet Charles³^ORCID,Tameire Feven⁴^ORCID,Evans Michael J.³^ORCID,Evans Christopher P.⁵^ORCID,Yang Joy C.⁵,Hann Byron⁶^ORCID,Koumenis Constantinos⁴^ORCID,Walter Peter⁷^ORCID,Carroll Peter R.¹,Ruggero Davide¹⁸^ORCID

Affiliation:

1. School of Medicine and Department of Urology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco (UCSF), San Francisco, CA 94158, USA.

2. Division of Pediatric Allergy, Immunology and Bone Marrow Transplantation, UCSF, San Francisco, CA 94158, USA.

3. Department of Radiology and Biomedical Imaging, UCSF, San Francisco, CA 94158, USA.

4. Department of Radiation Oncology, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

5. Department of Urology, University of California Davis School of Medicine, Sacramento, CA 95817, USA.

6. Helen Diller Family Comprehensive Cancer Center, UCSF, San Francisco, CA 94158, USA.

7. Department of Biochemistry and Biophysics, UCSF, Howard Hughes Medical Institute, San Francisco, CA 94158, USA.

8. Department of Cellular and Molecular Pharmacology, UCSF, San Francisco, CA 94158, USA.

Abstract

The PERK-eIF2α pathway is activated in aggressive prostate cancer and associated with patient outcome, providing a therapeutic target for the disease.

Funder

U.S. Department of Defense

American Cancer Society

Prostate Cancer Foundation

NIH

Urology Care Foundation Rising Star in research award

AACR-Bayer Prostate Cancer Research

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference54 articles.