Integrated pathogen load and dual transcriptome analysis of systemic host-pathogen interactions in severe malaria

Author:

Lee Hyun Jae1ORCID,Georgiadou Athina2ORCID,Walther Michael3,Nwakanma Davis3ORCID,Stewart Lindsay B.4,Levin Michael2,Otto Thomas D.5ORCID,Conway David J.4ORCID,Coin Lachlan J.1,Cunnington Aubrey J.2ORCID

Affiliation:

1. Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland 4072, Australia.

2. Section of Paediatrics, Imperial College, London W2 1PG, UK.

3. Medical Research Council Unit The Gambia at London School of Hygiene and Tropical Medicine, P.O. Box 273, Fajara, The Gambia.

4. Department of Pathogen Molecular Biology, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK.

5. Wellcome Trust Sanger Centre, Hinxton, Cambridge CB10 1SA, UK.

Abstract

Host and parasite RNA sequencing is combined with parasite load estimates to reveal mechanisms associated with human severe malaria.

Funder

Wellcome Trust

Medical Research Council

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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