A BMP/activin A chimera is superior to native BMPs and induces bone repair in nonhuman primates when delivered in a composite matrix-Reference-Cited by-同舟云学术

A BMP/activin A chimera is superior to native BMPs and induces bone repair in nonhuman primates when delivered in a composite matrix

Published:2019-04-24 Issue:489 Volume:11 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Seeherman Howard J.¹^ORCID,Berasi Stephen P.²,Brown Christopher T.¹,Martinez Robert X.³^ORCID,Juo Z. Sean⁴^ORCID,Jelinsky Scott³^ORCID,Cain Michael J.³,Grode Jaclyn¹^ORCID,Tumelty Kathleen E.²,Bohner Marc⁵^ORCID,Grinberg Orly⁶,Orr Nadav⁶,Shoseyov Oded⁶,Eyckmans Jeroen⁷⁸^ORCID,Chen Christopher⁷⁸^ORCID,Morales Pablo R.⁹,Wilson Christopher G.¹^ORCID,Vanderploeg Eric J.¹^ORCID,Wozney John M.¹

Affiliation:

1. Bioventus Surgical, Bioventus LLC, Boston, MA 02215, USA.

2. Centers for Therapeutic Innovation, Pfizer Inc., Boston, MA 02115, USA.

3. Department of Inflammation and Immunology, Pfizer Inc., Cambridge, MA 02139, USA.

4. Biomedical Design, Pfizer Inc., Cambridge, MA 02139, USA.

5. Robert Mathys Stiftung (RMS) Foundation, Bettlach 2544, Switzerland.

6. CollPlant Ltd., Ness Ziona 74140, Israel.

7. Biological Design Center and Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA.

8. Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA.

9. Mannheimer Foundation Inc., Homestead, FL 33034, USA.

Abstract

BV-265, a BMP-2/BMP-6/activin A chimera, delivered in a composite matrix generates bone repair in nonhuman primates at lower concentrations than BMP-2.

Funder

Pfizer

Bioventus

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference59 articles.

1. The Biology of Bone Grafting

2. Bone Morphogenetic Proteins

3. BMPs are mediators in tissue crosstalk of the regenerating musculoskeletal system

4. BMP2 activity, although dispensable for bone formation, is required for the initiation of fracture healing

5. Periosteal BMP2 activity drives bone graft healing

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