Intrinsic cell-penetrating activity propels Omomyc from proof of concept to viable anti-MYC therapy-Reference-Cited by-同舟云学术

Intrinsic cell-penetrating activity propels Omomyc from proof of concept to viable anti-MYC therapy

Published:2019-03-20 Issue:484 Volume:11 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Beaulieu Marie-Eve¹²^ORCID,Jauset Toni¹²,Massó-Vallés Daniel¹²^ORCID,Martínez-Martín Sandra²^ORCID,Rahl Peter³,Maltais Loïka⁴^ORCID,Zacarias-Fluck Mariano F.²^ORCID,Casacuberta-Serra Sílvia¹²^ORCID,Serrano del Pozo Erika²^ORCID,Fiore Christopher³^ORCID,Foradada Laia¹,Cano Virginia Castillo²^ORCID,Sánchez-Hervás Meritxell²,Guenther Matthew³,Romero Sanz Eduardo⁵^ORCID,Oteo Marta⁵,Tremblay Cynthia⁴^ORCID,Martín Génesis²,Letourneau Danny⁴^ORCID,Montagne Martin⁴^ORCID,Morcillo Alonso Miguel Ángel⁵^ORCID,Whitfield Jonathan R.²^ORCID,Lavigne Pierre⁴,Soucek Laura¹²⁶⁷^ORCID

Affiliation:

1. Peptomyc S.L., Edifici Cellex, Hospital Vall d’Hebron, Barcelona, 08035, Spain.

2. Vall d’Hebron Institute of Oncology (VHIO), Edifici Cellex, Hospital Vall d’Hebron, Barcelona, 08035, Spain.

3. Syros Pharmaceuticals, Cambridge, MA 02139, USA.

4. Département de Biochimie, PROTÉO and Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, Sherbrooke, Quebec J1H 5N4, Canada.

5. Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (CIEMAT), Madrid, 28040, Spain.

6. Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, 08010, Spain.

7. Department of Biochemistry and Molecular Biology, Universitat Autònoma de Barcelona, Bellaterra, 08193 , Spain.

Abstract

We demonstrate the pharmacologic potential of the purified cell-penetrating Omomyc mini-protein to directly inhibit MYC function in vitro and in vivo.

Funder

Fundacion BBVA

H2020 European Research Council

Worldwide Cancer Research

Fonds de Recherche du Québec - Santé

Ministerio de Economía y Competitividad

Instituto de Salud Carlos III

FERO Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine