A digital microfluidic system for serological immunoassays in remote settings

Author:

Ng Alphonsus H. C.12ORCID,Fobel Ryan12ORCID,Fobel Christian12ORCID,Lamanna Julian12ORCID,Rackus Darius G.12ORCID,Summers Aimee3,Dixon Christopher1ORCID,Dryden Michael D. M.1ORCID,Lam Charis1ORCID,Ho Man12ORCID,Mufti Nooman S.24,Lee Victor2ORCID,Asri Mohd Afiq Mohd2,Sykes Edward A.12,Chamberlain M. Dean12ORCID,Joseph Rachael5,Ope Maurice5,Scobie Heather M.6,Knipes Alaine3ORCID,Rota Paul A.7ORCID,Marano Nina8,Chege Paul M.9,Njuguna Mary9,Nzunza Rosemary9ORCID,Kisangau Ngina9,Kiogora John10,Karuingi Michael10ORCID,Burton John Wagacha11,Borus Peter12,Lam Eugene3,Wheeler Aaron R.124ORCID

Affiliation:

1. Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Ontario M5S 3H6, Canada.

2. Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada.

3. Division of Global Health Protection, Centers for Disease Control and Prevention, 1600 Clifton Road Northeast, Atlanta, GA 30329, USA.

4. Institute of Biomaterials and Biomedical Engineering, University of Toronto, 164 College Street, Toronto, Ontario M5S 3G9, Canada.

5. Centers for Disease Control and Prevention, Kenya Medical Research Institute (KEMRI) Complex, P.O. Box 606-00621, Mbagathi Road Off Mbagathi Way, Village Market, Nairobi, Kenya.

6. Global Immunization Division, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA.

7. Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA.

8. Division of Global Migration and Quarantine, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA.

9. Kenya Field Epidemiology and Laboratory Training Program, Ministry of Health, P.O. Box 30016–00100, Afya House, Cathedral Road, Nairobi, Kenya.

10. International Rescue Committee, P.O. Box 62727, Galana Plaza, 4th Floor Galana Road, Kilimani, Nairobi, Kenya.

11. Office of the United Nations High Commissioner for Refugees, P.O. Box 43801-00100, Lynwood Court, Off Waiyaki Way, Westland, Nairobi, Kenya.

12. KEMRI, P.O. Box 54840-00200, Off Mbagathi Road, Nairobi, Kenya.

Abstract

Portable digital microfluidic serological immunoassays for measles and rubella were developed and evaluated in a remote setting.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference67 articles.

1. “Measles Fact Sheet ” (WHO Publication 2016; www.who.int/mediacentre/factsheets/fs286/en/).

2. “Rubella Fact Sheet ” (WHO Publication 2016; www.who.int/mediacentre/factsheets/fs367/en/).

3. Vaccine-preventable diseases in humanitarian emergencies among refugee and internally-displaced populations

4. “Global measles and rubella strategic plan: 2012–2020” (WHO Publication 2016); http://apps.who.int/iris/bitstream/10665/44855/1/9789241503396_eng.pdf.

5. Use of serological surveys to generate key insights into the changing global landscape of infectious disease

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