PD-1 up-regulation on CD4 + T cells promotes pulmonary fibrosis through STAT3-mediated IL-17A and TGF-β1 production

Author:

Celada Lindsay J.1ORCID,Kropski Jonathan A.2,Herazo-Maya Jose D.3,Luo Weifeng1,Creecy Amy4,Abad Andrew T.1ORCID,Chioma Ozioma S.1,Lee Grace1,Hassell Natalie E.1,Shaginurova Guzel I.1ORCID,Wang Yufen1,Johnson Joyce E.5ORCID,Kerrigan Amy1,Mason Wendi R.2,Baughman Robert P.6,Ayers Gregory D.7,Bernard Gordon R.2ORCID,Culver Daniel A.8,Montgomery Courtney G.49ORCID,Maher Toby M.1011ORCID,Molyneaux Philip L.1011ORCID,Noth Imre12,Mutsaers Steven E.1314ORCID,Prele Cecilia M.1314,Stokes Peebles R.25,Newcomb Dawn C.25,Kaminski Naftali3ORCID,Blackwell Timothy S.2,Van Kaer Luc5ORCID,Drake Wonder P.15ORCID

Affiliation:

1. Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.

2. Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.

3. Section of Pulmonary, Critical Care, and Sleep Medicine, Yale School of Medicine, New Haven, CT 06510, USA.

4. Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.

5. Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.

6. Division of Pulmonary, Critical Care and Sleep Medicine, University of Cincinnati Medical Center, Cincinnati, OH 45219, USA.

7. Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.

8. Respiratory Institute, Cleveland Clinic, Cleveland, OH 44195, USA.

9. Department of Biostatistics and Epidemiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73126, USA.

10. National Institute for Health Research Respiratory Biomedical Research Unit, Royal Brompton Hospital, London SW7 2AZ, UK.

11. Fibrosis Research Group, National Heart and Lung Institute, Imperial College, London SW7 2AZ, UK.

12. Section of Pulmonary and Critical Care Medicine, University of Chicago, Chicago, IL 60637, USA.

13. Centre for Cell Therapy and Regenerative Medicine, School of Biomedical Sciences, University of Western Australia, Nedlands, Western Australia 6009, Australia.

14. Institute for Respiratory Health, Centre for Respiratory Health, School of Biomedical Sciences, University of Western Australia, Nedlands, Western Australia 6009, Australia.

Abstract

PD-1 + T H 17 cells enhance collagen-1 production from human lung fibroblasts.

Funder

National Institutes of Health

National Heart, Lung, and Blood Institute

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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