CD32 is expressed on cells with transcriptionally active HIV but does not enrich for HIV DNA in resting T cells-Reference-Cited by-同舟云学术

CD32 is expressed on cells with transcriptionally active HIV but does not enrich for HIV DNA in resting T cells

Published:2018-04-18 Issue:437 Volume:10 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Abdel-Mohsen Mohamed¹^ORCID,Kuri-Cervantes Leticia²^ORCID,Grau-Exposito Judith³^ORCID,Spivak Adam M.⁴^ORCID,Nell Racheal A.⁴^ORCID,Tomescu Costin¹,Vadrevu Surya Kumari¹^ORCID,Giron Leila B.¹^ORCID,Serra-Peinado Carla³^ORCID,Genescà Meritxell³^ORCID,Castellví Josep⁵^ORCID,Wu Guoxin⁶,Del Rio Estrada Perla M.⁷^ORCID,González-Navarro Mauricio⁷^ORCID,Lynn Kenneth¹²⁸,King Colin T.⁹,Vemula Sai⁶,Cox Kara⁶^ORCID,Wan Yanmin¹⁰,Li Qingsheng¹⁰^ORCID,Mounzer Karam⁸^ORCID,Kostman Jay⁸,Frank Ian²,Paiardini Mirko⁹,Hazuda Daria⁶^ORCID,Reyes-Terán Gustavo⁷,Richman Douglas¹¹,Howell Bonnie⁶^ORCID,Tebas Pablo²^ORCID,Martinez-Picado Javier¹²¹³¹⁴,Planelles Vicente⁴,Buzon Maria J.³^ORCID,Betts Michael R.²,Montaner Luis J.¹^ORCID

Affiliation:

1. The Wistar Institute, Philadelphia, PA 19104, USA.

2. Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

3. Department of Infectious Diseases, Hospital Universitari Vall d’Hebrón, Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Barcelona 08035, Spain.

4. University of Utah School of Medicine, Salt Lake City, UT 84132, USA.

5. Department of Pathology, Hospital Universitari Vall d´Hebrón, Barcelona 08035, Spain.

6. Merck & Co. Inc., Kenilworth, NJ 07033, USA.

7. Instituto Nacional de Enfermedades Respiratorias, Tlalpan 14080, Mexico City, Mexico.

8. Jonathan Lax Center, Philadelphia FIGHT, Philadelphia, PA 19107, USA.

9. Emory University, Atlanta, GA 30322, USA.

10. University of Nebraska–Lincoln, Lincoln, NE 68588, USA.

11. Veterans Affairs San Diego Healthcare System and University of California, San Diego, San Diego, CA 92093, USA.

12. IrsiCaixa AIDS Research Institute, Badalona 08916, Barcelona, Spain.

13. University of Vic–Central University of Catalonia (UVic-UCC), Vic 08500, Barcelona, Spain.

14. Catalan Institution for Research and Advanced Studies (ICREA), Barcelona 08908, Catalonia, Spain.

Abstract

CD32 is associated with highly activated T cells harboring HIV RNA transcripts and does not enrich for HIV DNA in resting T cells.

Funder

National Institutes of Health

National Institutes of Heath

W.W. Smith Charitable Trust

Penn Center for AIDS Research

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference53 articles.

1. Recovery of Replication-Competent HIV Despite Prolonged Suppression of Plasma Viremia

2. HIV Infection, Inflammation, Immunosenescence, and Aging

3. Defining total-body AIDS-virus burden with implications for curative strategies

4. B cell follicle sanctuary permits persistent productive simian immunodeficiency virus infection in elite controllers

5. CTLA-4+PD-1− Memory CD4+ T Cells Critically Contribute to Viral Persistence in Antiretroviral Therapy-Suppressed, SIV-Infected Rhesus Macaques

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