The fragile X mutation impairs homeostatic plasticity in human neurons by blocking synaptic retinoic acid signaling-Reference-Cited by-同舟云学术

The fragile X mutation impairs homeostatic plasticity in human neurons by blocking synaptic retinoic acid signaling

Published:2018-08 Issue:452 Volume:10 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Zhang Zhenjie¹^ORCID,Marro Samuele G.²³^ORCID,Zhang Yingsha⁴,Arendt Kristin L.¹^ORCID,Patzke Christopher⁴,Zhou Bo⁴,Fair Tyler²³,Yang Nan²³,Südhof Thomas C.⁴⁵^ORCID,Wernig Marius²³,Chen Lu¹^ORCID

Affiliation:

1. Departments of Neurosurgery, and Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 265 Campus Drive, Stanford, CA 94305–5453, USA.

2. Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305–5453, USA.

3. Institute of Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305–5453, USA.

4. Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305–5453, USA.

5. Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305–5453, USA.

Abstract

Inactivation of the Fmr1 gene that is mutated in fragile X syndrome leads to loss of retinoic acid–mediated homeostatic plasticity in human neurons.

Funder

U.S. Department of Defense

Howard Hughes Medical Institute

National Institute of Mental Health

New York Stem Cell Foundation

Eunice Kennedy Shriver National Institute of Child Health and Human Development

FRAXA Research Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference95 articles.

1. Molecular Mechanisms of Fragile X Syndrome: A Twenty-Year Perspective

2. Fragile X syndrome: causes, diagnosis, mechanisms, and therapeutics

3. Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome

4. Variation of the CGG repeat at the fragile X site results in genetic instability: Resolution of the Sherman paradox

5. Inheritance of the fragile X syndrome: size of the fragile X premutation is a major determinant of the transition to full mutation.

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