Aminomethyl spectinomycins as therapeutics for drug-resistant respiratory tract and sexually transmitted bacterial infections-Reference-Cited by-同舟云学术

Aminomethyl spectinomycins as therapeutics for drug-resistant respiratory tract and sexually transmitted bacterial infections

Published:2015-05-20 Issue:288 Volume:7 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Bruhn David F.¹,Waidyarachchi Samanthi L.¹,Madhura Dora B.²,Shcherbakov Dimitri³,Zheng Zhong¹,Liu Jiuyu¹,Abdelrahman Yasser M.⁴⁵,Singh Aman P.¹⁶,Duscha Stefan³,Rathi Chetan²,Lee Robin B.¹,Belland Robert J.⁴,Meibohm Bernd²,Rosch Jason W.⁷,Böttger Erik C.³,Lee Richard E.¹

Affiliation:

1. Department of Chemical Biology and Therapeutics, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA.

2. Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN 38163, USA.

3. Institut für Medizinische Mikrobiologie, Universität Zürich, Zürich 8006, Switzerland.

4. Department of Microbiology, Immunology, and Biochemistry, University of Tennessee Health Science Center, Memphis, TN 38163, USA.

5. Department of Microbiology and Immunology, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt.

6. Biomedical Sciences Graduate Program, University of Tennessee Health Science Center, Memphis, TN 38163, USA.

7. Infectious Diseases Department, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA.

Abstract

A new series of spectinomycin analogs with potency against drug-resistant bacterial pathogens was designed and developed with a structure-based approach and validated in vitro and in vivo.

Funder

NIH

American Lebanese Syrian Associated Charities (ALSAC)

SJCRH

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference46 articles.

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5. Natural Products as Sources of New Drugs over the Last 25 Years

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