A long-acting integrase inhibitor protects female macaques from repeated high-dose intravaginal SHIV challenge-Reference-Cited by-同舟云学术

A long-acting integrase inhibitor protects female macaques from repeated high-dose intravaginal SHIV challenge

Published:2015-01-14 Issue:270 Volume:7 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Andrews Chasity D.¹,Yueh Yun Lan²,Spreen William R.²,St. Bernard Leslie¹,Boente-Carrera Mar¹,Rodriguez Kristina¹,Gettie Agegnehu¹,Russell-Lodrigue Kasi³,Blanchard James³,Ford Susan²,Mohri Hiroshi¹,Cheng-Mayer Cecilia¹,Hong Zhi²,Ho David D.¹,Markowitz Martin¹

Affiliation:

1. Aaron Diamond AIDS Research Center, The Rockefeller University, New York, NY 10016, USA.

2. GlaxoSmithKline, Research Triangle Park, NC 27709, USA.

3. Tulane National Primate Research Center, Covington, LA 70433, USA.

Abstract

The long-acting integrase inhibitor GSK744 protects macaques from three high-dose SHIV challenges at plasma drug concentrations that could be achieved with quarterly injections in humans.

Funder

NIH

Tulane National Primate Research Center

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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