A synthetic fibrin cross-linking polymer for modulating clot properties and inducing hemostasis-Reference-Cited by-同舟云学术

A synthetic fibrin cross-linking polymer for modulating clot properties and inducing hemostasis

Published:2015-03-04 Issue:277 Volume:7 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Chan Leslie W.¹,Wang Xu²,Wei Hua¹,Pozzo Lilo D.³,White Nathan J.²,Pun Suzie H.¹

Affiliation:

1. Department of Bioengineering and Molecular Engineering and Sciences Institute, University of Washington, 3720 15th Avenue Northeast, Box 355061, Seattle, WA 98195, USA.

2. Division of Emergency Medicine, Department of Medicine, University of Washington, Seattle, WA 98195, USA.

3. Department of Chemical Engineering, University of Washington, Seattle, WA 98195, USA.

Abstract

By cross-linking fibrin, intravenously injected factor XIII–inspired hemostatic polymers stabilize clots and reduce bleeding in a rat model of trauma and fluid resuscitation.

Funder

NIH

Washington Research Foundation

Institute of Translational Health Sciences

NIH National Center for Advancing Translational Sciences

Bioengineering Cardiovascular Training

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference39 articles.

1. Epidemiology of Trauma Deaths