In vivo tracking of T cells in humans unveils decade-long survival and activity of genetically modified T memory stem cells-Reference-Cited by-同舟云学术

In vivo tracking of T cells in humans unveils decade-long survival and activity of genetically modified T memory stem cells

Published:2015-02-04 Issue:273 Volume:7 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Biasco Luca¹,Scala Serena¹²,Basso Ricci Luca¹,Dionisio Francesca¹,Baricordi Cristina¹,Calabria Andrea¹,Giannelli Stefania¹,Cieri Nicoletta³,Barzaghi Federica⁴,Pajno Roberta⁴,Al-Mousa Hamoud⁵,Scarselli Alessia⁶,Cancrini Caterina⁶,Bordignon Claudio²,Roncarolo Maria Grazia¹²,Montini Eugenio¹,Bonini Chiara³,Aiuti Alessandro⁶⁷

Affiliation:

1. San Raffaele Telethon Institute for Gene Therapy (TIGET), Division of Regenerative Medicine, Stem Cells, and Gene Therapy, Istituti di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele Scientific Institute, Milan 20132, Italy.

2. Vita-Salute San Raffaele University, Milan 20132, Italy.

3. IRCCS San Raffaele Scientific Institute, Milan 20132, Italy.

4. Pediatric Immunohematology and Stem Cell Programme, IRCCS San Raffaele Scientific Institute, Milan 20132, Italy.

5. King Faisal Specialist Hospital & Research Centre, Riyadh 11211, Saudi Arabia.

6. Department of Pediatrics, Ospedale Pediatrico Bambino Gesù and University of Rome “Tor Vergata,” Rome 00165, Italy.

7. TIGET, Pediatric Immunohematology and Stem Cell Programme, San Raffaele Scientific Institute, Milan 20132, Italy.

Abstract

Genetically engineered T memory stem cells preserve differentiation activity for decades after patient infusion.

Funder

Italian Telethon Foundation

Italian Ministero della Salute

Advanced Cell_based Therapies for the treatment of Primary ImmunoDeficiency

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference49 articles.

1. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions

2. Diversity in T Cell Memory: An Embarrassment of Riches

3. Human memory T cells: generation, compartmentalization and homeostasis

4. Proliferation and differentiation potential of human CD8+ memory T-cell subsets in response to antigen or homeostatic cytokines

5. A human memory T cell subset with stem cell–like properties

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