IGF2 is an actionable target that identifies a distinct subpopulation of colorectal cancer patients with marginal response to anti-EGFR therapies-Reference-Cited by-同舟云学术

IGF2 is an actionable target that identifies a distinct subpopulation of colorectal cancer patients with marginal response to anti-EGFR therapies

Published:2015-01-28 Issue:272 Volume:7 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Zanella Eugenia R.¹²,Galimi Francesco¹²,Sassi Francesco¹²,Migliardi Giorgia¹²,Cottino Francesca²,Leto Simonetta M.¹²,Lupo Barbara¹²,Erriquez Jessica³,Isella Claudio¹⁴,Comoglio Paolo M.¹⁵,Medico Enzo¹⁴,Tejpar Sabine⁶,Budinská Eva⁷⁸,Trusolino Livio¹²,Bertotti Andrea¹²⁹

Affiliation:

1. Department of Oncology, University of Torino Medical School, 10060 Candiolo, Torino, Italy.

2. Translational Cancer Medicine, Candiolo Cancer Institute–Fondazione del Piemonte per l’Oncologia (FPO) Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 10060 Candiolo, Torino, Italy.

3. Cancer Genetics, Candiolo Cancer Institute–FPO IRCCS, 10060 Candiolo, Torino, Italy.

4. Oncogenomics, Candiolo Cancer Institute–FPO IRCCS, 10060 Candiolo, Torino, Italy.

5. Molecular Clinical Oncology, Candiolo Cancer Institute–FPO IRCCS, 10060 Candiolo, Torino, Italy.

6. University Hospital Gasthuisberg, 3000 Leuven, Belgium.

7. Institute of Biostatistics and Analyses, Masaryk University, 611 37 Brno, Czech Republic.

8. Regional Center of Applied Molecular Oncology, Masaryk Memorial Cancer Institute, 656 53 Brno, Czech Republic.

9. National Institute of Biostructures and Biosystems, 00136 Rome, Italy.

Abstract

Colorectal cancers that display reduced sensitivity to EGFR inhibition and strong IGF2 overexpression can be effectively treated by dual EGFR/IGF2 blockade.

Funder

American Association for Cancer Research

Ministero dell'Universita e della Ricerca

Associazione Italiana per la Ricerca sul Cancro

AIRC Investigator

European Regional Development Fund

Fondo per gli Investimenti della Ricerca di Base_Futuro in Ricercaq

Fondazione Piemontese per la Ricerca sul Cancro-ONLUS

State Budget of the Czech Republic-RECAMO

Publisher

American Association for the Advancement of Science (AAAS)

Subject