Surface-enhanced resonance Raman scattering nanostars for high-precision cancer imaging

Author:

Harmsen Stefan1,Huang Ruimin12,Wall Matthew A.13,Karabeber Hazem1,Samii Jason M.1,Spaliviero Massimiliano4,White Julie R.56,Monette Sébastien56,O’Connor Rachael7,Pitter Kenneth L.6,Sastra Stephen A.89,Saborowski Michael6,Holland Eric C.10,Singer Samuel7,Olive Kenneth P.89,Lowe Scott W.611,Blasberg Ronald G.12121314,Kircher Moritz F.121215

Affiliation:

1. Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

2. Brain Tumor Center, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

3. Department of Chemistry, Hunter College, City University of New York, New York, NY 10065, USA.

4. Urology Service, Department of Surgery, Sidney Kimmel Center for Prostate and Urologic Cancers, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

5. Tri-Institutional Laboratory of Comparative Pathology, Memorial Sloan Kettering Cancer Center, The Rockefeller University, and Weill Cornell Medical College, New York, NY 10065, USA.

6. Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

7. Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

8. Department of Medicine, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA.

9. Department of Pathology and Cell Biology, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA.

10. Human Biology Division and Solid Tumor Translational Research, Fred Hutchinson Cancer Research Center, Alvord Brain Tumor Center, University of Washington, Seattle, WA 98109, USA.

11. Howard Hughes Medical Institute, New York, NY 10065, USA.

12. Center for Molecular Imaging and Nanotechnology (CMINT), Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

13. Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

14. Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

15. Department of Radiology, Weill Cornell Medical College, New York, NY 10065, USA.

Abstract

Surface-enhanced resonance Raman scattering gold nanostars allow detection of macro- and microscopic foci of premalignant and cancerous lesions in vivo.

Funder

NIH

NCI

Damon Runyon Cancer Research Foundation

The Dana Foundation Brain and Immuno-Imaging

Dana Neuroscience Scholar Award

Bayer HealthCare Pharmaceuticals/Radiological Society of North America Research Scholar

MSKCC Center for Molecular Imaging and Nanotechnology

MSKCC Technology Development

Geoffrey Beene Cancer Research Center at MSKCC

Shared Resources Award

MSKCC Brain Tumor Center

Society of MSKCC Research

National Science Foundation Integrative Graduate Education and Research Traineeship

MSKCC NIH Core

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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