Obesity-dependent changes in interstitial ECM mechanics promote breast tumorigenesis-Reference-Cited by-同舟云学术

Obesity-dependent changes in interstitial ECM mechanics promote breast tumorigenesis

Published:2015-08-19 Issue:301 Volume:7 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Seo Bo Ri¹,Bhardwaj Priya²,Choi Siyoung¹,Gonzalez Jacqueline¹,Andresen Eguiluz Roberto C.³,Wang Karin¹³,Mohanan Sunish⁴,Morris Patrick G.⁵,Du Baoheng²,Zhou Xi K.⁶,Vahdat Linda T.²,Verma Akanksha⁷,Elemento Olivier⁷,Hudis Clifford A.⁵,Williams Rebecca M.¹,Gourdon Delphine³,Dannenberg Andrew J.²,Fischbach Claudia¹⁸

Affiliation:

1. Department of Biomedical Engineering, Cornell University, Ithaca, NY 14853, USA.

2. Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA.

3. Department of Materials Science and Engineering, Cornell University, Ithaca, NY 14853, USA.

4. Department of Biological and Biomedical Sciences, Cornell University, Ithaca, NY 14853, USA.

5. Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

6. Department of Healthcare Policy and Research, Weill Cornell Medical College, New York, NY 10065, USA.

7. Department of Physiology and Biophysics, Institute for Computational Biomedicine, Weill Cornell Medical College, New York, NY 10065, USA.

8. Kavli Institute at Cornell for Nanoscale Science, Cornell University, Ithaca, NY 14853, USA.

Abstract

Obesity leads to fibrotic remodeling of mammary adipose tissue, and the resulting increase in interstitial extracellular matrix stiffness promotes breast tumor malignancy.

Funder

National Science Foundation

NIH/NCI (National Cancer Institute)

Breast Cancer Research Foundation

Clinical and Translational Science Center at Weill Cornell Medical College

Botwinick-Wolfensohn Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference58 articles.

1. Adipocytes: Impact on tumor growth and potential sites for therapeutic intervention