Ectopic activation of the miR-200c–EpCAM axis enhances antitumor T cell responses in models of adoptive cell therapy-Reference-Cited by-同舟云学术

Ectopic activation of the miR-200c–EpCAM axis enhances antitumor T cell responses in models of adoptive cell therapy

Published:2021-09-15 Issue:611 Volume:13 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Zhang Minggang¹^ORCID,Zhao Zeguo¹²^ORCID,Pritykin Yuri³^ORCID,Hannum Margaret⁴,Scott Andrew C.¹^ORCID,Kuo Fengshen⁵^ORCID,Sanghvi Viraj⁶^ORCID,Chan Timothy A.⁵,Seshan Venkatraman⁴,Wendel Hans-Guido⁶^ORCID,Schietinger Andrea¹,Sadelain Michel¹²^ORCID,Huse Morgan¹^ORCID

Affiliation:

1. Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

2. Center for Cell Engineering, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

3. Lewis-Sigler Institute for Integrative Genomics and Computer Science Department, Princeton University, Princeton, NJ 08540, USA.

4. Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

5. Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

6. Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

Abstract

Up-regulation of the miR-200c–EpCAM axis promotes the engraftment, persistence, and antitumor activity of transferred T cells in murine models.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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