Dengue and Zika virus infections in children elicit cross-reactive protective and enhancing antibodies that persist long term

Author:

Katzelnick Leah C.12ORCID,Zambrana Jose Victor3ORCID,Elizondo Douglas3,Collado Damaris3ORCID,Garcia Nadezna3,Arguello Sonia3,Mercado Juan Carlos34,Miranda Tatiana3ORCID,Ampie Oscarlett3ORCID,Mercado Brenda Lopez3ORCID,Narvaez César3,Gresh Lionel3ORCID,Binder Raquel A.13ORCID,Ojeda Sergio3ORCID,Sanchez Nery3ORCID,Plazaola Miguel3ORCID,Latta Krista5ORCID,Schiller Amy5ORCID,Coloma Josefina1ORCID,Carrillo Fausto Bustos1ORCID,Narvaez Federico3ORCID,Halloran M. Elizabeth67ORCID,Gordon Aubree5ORCID,Kuan Guillermina38ORCID,Balmaseda Angel34,Harris Eva1ORCID

Affiliation:

1. Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA 94720-3370, USA.

2. Viral Epidemiology and Immunity Unit, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-3203, USA.

3. Sustainable Sciences Institute, Managua 14007, Nicaragua.

4. Laboratorio Nacional de Virología, Centro Nacional de Diagnóstico y Referencia, Ministry of Health, Managua 16064, Nicaragua.

5. Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109-2029, USA.

6. Department of Biostatistics, University of Washington, Seattle, WA 98195-1617, USA.

7. Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109-1024, USA.

8. Centro de Salud Sócrates Flores Vivas, Ministry of Health, Managua 12014, Nicaragua.

Abstract

Unexpectedly, cross-reactive antibodies are stable or rise after primary dengue and Zika virus infection and wane slowly after secondary infection.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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