Targeting AKR1B1 inhibits glutathione de novo synthesis to overcome acquired resistance to EGFR-targeted therapy in lung cancer-Reference-Cited by-同舟云学术

Targeting AKR1B1 inhibits glutathione de novo synthesis to overcome acquired resistance to EGFR-targeted therapy in lung cancer

Published:2021-10-06 Issue:614 Volume:13 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Zhang Ke-Ren¹^ORCID,Zhang Yu-Fei¹^ORCID,Lei Hui-Min¹^ORCID,Tang Ya-Bin¹^ORCID,Ma Chun-Shuang¹,Lv Qian-Ming¹,Wang Shi-Yi¹,Lu Li-Ming²^ORCID,Shen Ying¹^ORCID,Chen Hong-Zhuan³^ORCID,Zhu Liang¹^ORCID

Affiliation:

1. Department of Pharmacology and Chemical Biology, College of Basic Medical Sciences and Respiratory Department, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.

2. Central Laboratory, Shanghai Chest Hospital and Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.

3. Department of Clinical Pharmacy, Institute of Interdisciplinary Integrative Biomedical Research, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.

Abstract

AKR1B1 boosts glutathione de novo synthesis as a metabolic mechanism driving resistance to EGFR-targeted therapy in mouse models of lung cancer.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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