Axonal marker neurofilament light predicts long-term outcomes and progressive neurodegeneration after traumatic brain injury-Reference-Cited by-同舟云学术

Axonal marker neurofilament light predicts long-term outcomes and progressive neurodegeneration after traumatic brain injury

Published:2021-09-29 Issue:613 Volume:13 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Graham Neil S. N.¹²^ORCID,Zimmerman Karl A.¹²^ORCID,Moro Federico³⁴^ORCID,Heslegrave Amanda⁵⁶^ORCID,Maillard Samia Abed⁷,Bernini Adriano⁷^ORCID,Miroz John-Paul⁷,Donat Cornelius K.¹,Lopez Maria Yanez⁸^ORCID,Bourke Niall¹²^ORCID,Jolly Amy E.¹²^ORCID,Mallas Emma-Jane¹²^ORCID,Soreq Eyal¹²^ORCID,Wilson Mark H.⁹¹⁰^ORCID,Fatania Gavin¹¹,Roi Dylan¹¹,Patel Maneesh C.¹¹,Garbero Elena¹²^ORCID,Nattino Giovanni¹²^ORCID,Baciu Camelia¹³^ORCID,Fainardi Enrico¹⁴,Chieregato Arturo¹³^ORCID,Gradisek Primoz¹⁵^ORCID,Magnoni Sandra¹⁶,Oddo Mauro⁷¹⁷^ORCID,Zetterberg Henrik¹⁸¹⁹^ORCID,Bertolini Guido¹²^ORCID,Sharp David J.¹²²⁰^ORCID

Affiliation:

1. Department of Brain Sciences, Imperial College London, London W12 0NN, UK.

2. UK DRI Centre for Care Research and Technology, Imperial College London, London W12 0BZ, UK.

3. Laboratory of Acute Brain Injury and Therapeutic Strategies, Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri IRCCS 20156, Milan, Italy.

4. Fondazione IRCCS, Ca’ Granda Ospedale Maggiore Policlinico, Dipartimento di Anestesia e Rianimazione, 20122, Milan, Italy.

5. Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK.

6. UK Dementia Research Institute at UCL, London WC1N 3BG, UK.

7. Neuroscience Critical Care Research Group, Department of Intensive Care Medicine, CHUV Lausanne University Hospital and University of Lausanne, Lausanne 1011, Switzerland.

8. Centre for the Developing Brain, School of Biomedical Engineering and Imaging Sciences, King’s College London, London SE1 7EH, UK.

9. Department of Neurosurgery, Imperial College Healthcare NHS Trust, London W6 8RF, UK.

10. Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London SW7 2AZ, UK.

11. Department of Imaging, Imperial College Healthcare NHS Trust, London W6 8RF, UK.

12. Laboratory of Clinical Epidemiology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Bergamo 24126, Italy.

13. Neurorianimazione, ASST Grande Ospedale Metropolitano Niguarda, Milano 20162, Italy.

14. Department of Experimental and Clinical Sciences, Careggi University Hospital, University of Firenze, Florence 50139, Italy.

15. Clinical Department of Anaesthesiology and Intensive Therapy, University Medical Center, Ljubljana 1000, Slovenia.

16. Department of Anesthesia and Intensive Care, Santa Chiara Hospital, Trento 38122, Italy.

17. Medical Direction, CHUV Lausanne University Hospital, Lausanne 1011, Switzerland.

18. Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Mölndal 431 41, Sweden.

19. Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal 431 41, Sweden.

20. Centre for Injury Studies, Imperial College London, London SW7 2AZ, UK.

Abstract

Axonal injury after TBI can be reliably quantified using plasma NfL, which predicts long-term functional outcomes and progressive neurodegeneration.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference69 articles.

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2. Functional outcome 10 years after traumatic brain injury: Its relationship with demographic, injury severity, and cognitive and emotional status

3. Disability in young people and adults after head injury: 5-7 year follow up of a prospective cohort study