A small molecule targeting ALOX12-ACC1 ameliorates nonalcoholic steatohepatitis in mice and macaques

Author:

Zhang Xiao-Jing123ORCID,Ji Yan-Xiao23ORCID,Cheng Xu12ORCID,Cheng Yanjie24ORCID,Yang Hailong12,Wang Junyong12ORCID,Zhao Ling-Ping23,Huang Yong-Ping25ORCID,Sun Dating12ORCID,Xiang Hui12ORCID,Shen Li-Jun12ORCID,Li Peng-Long23ORCID,Ma Jun-Peng23ORCID,Tian Rui-Feng12ORCID,Yang Juan12,Yao Xinxin23,Xu Haibo6ORCID,Liao Rufang6,Xiao Li7,Zhang Peng23,Zhang Xin2,Zhao Guang-Nian24ORCID,Wang Xi12,Hu Man-Li24ORCID,Tian Song12ORCID,Wan Juan12ORCID,Cai Jingjing8ORCID,Ma Xinliang9ORCID,Xu Qingbo10ORCID,Wang Yibin11ORCID,Touyz Rhian M.12ORCID,Liu Peter P.13ORCID,Loomba Rohit14ORCID,She Zhi-Gang12ORCID,Li Hongliang1234ORCID

Affiliation:

1. Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, China.

2. Institute of Model Animal of Wuhan University, Wuhan 430071, China.

3. School of Basic Medical Sciences, Wuhan University, Wuhan 430071, China.

4. Medical Science Research Center, Zhongnan Hospital of Wuhan University, Wuhan 430071, China.

5. College of Life Sciences, Wuhan University, Wuhan 430072, China.

6. Department of Radiology, Zhongnan Hospital of Wuhan University, Wuhan 430071, China.

7. Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

8. Department of Cardiology, The Third Xiangya Hospital, Central South University, Changsha 410013, China.

9. Department of Emergency Medicine, Thomas Jefferson University, Philadelphia, PA 19004, USA.

10. Centre for Clinic Pharmacology, The William Harvey Research Institute, Queen Mary University of London, London SE5 9NU, UK.

11. Department of Anesthesiology, Cardiovascular Research Laboratories, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.

12. British Heart Foundation Chair in Cardiovascular Medicine, and Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G12 8TA, UK.

13. Division of Cardiology, Department of Medicine, University of Ottawa Heart Institute, Ottawa, Ontario K1Y 4W7, Canada.

14. NAFLD Research Center, Division of Gastroenterology and Epidemiology, University of California, San Diego, San Diego, CA 92093, USA.

Abstract

IMA-1 targets the ALOX12-ACC1 interaction to both prevent and treat NASH without inducing hyperlipidemia.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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