Ebola vaccine–induced protection in nonhuman primates correlates with antibody specificity and Fc-mediated effects

Author:

Meyer Michelle12ORCID,Gunn Bronwyn M.3ORCID,Malherbe Delphine C.12,Gangavarapu Karthik45ORCID,Yoshida Asuka6ORCID,Pietzsch Colette12ORCID,Kuzmina Natalia A.12ORCID,Saphire Erica Ollmann7ORCID,Collins Peter L.8ORCID,Crowe James E.91011ORCID,Zhu James J.12,Suchard Marc A.13ORCID,Brining Douglas L.14,Mire Chad E.215ORCID,Cross Robert W.215ORCID,Geisbert Joan B.215,Samal Siba K.6ORCID,Andersen Kristian G.45ORCID,Alter Galit3ORCID,Geisbert Thomas W.215ORCID,Bukreyev Alexander1215ORCID

Affiliation:

1. Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA.

2. Galveston National Laboratory, Galveston, TX 77555, USA.

3. Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.

4. Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.

5. Scripps Research Translational Institute, La Jolla, CA 92037, USA.

6. Virginia-Maryland Regional College of Veterinary Medicine, University of Maryland, MD 20742, USA.

7. La Jolla Institute for Immunology, La Jolla, CA 92037, USA.

8. RNA Virology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20814, USA.

9. Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

10. Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

11. Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

12. USDA-ARS, FADRU, Plum Island Animal Disease Center, Orient, NY 11957, USA.

13. Departments of Biomathematics, Biostatistics and Human Genetics, University of California, Los Angeles, CA 90095, USA.

14. Animal Resource Center, University of Texas Medical Branch, Galveston, TX 77555, USA.

15. Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA.

Abstract

Fc effector functions and antibody specificity, rather than IgG or neutralizing titers, may serve as protective correlates for Ebola vaccines.

Funder

National Institute of Allergy and Infectious Diseases

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference61 articles.

1. WHO Ebola virus disease (2020); www.who.int/news-room/fact-sheets/detail/ebola-virus-disease.

2. Electronic Code of Federal Regulations. e-CFR Approval of new drugs when human efficacy studies are not ethical or feasible (2020); www.ecfr.gov/cgi-bin/text-idx?SID=07ae7117f4af9184631f0ba5ab8e9bec;mc=true;node=sp21.5.314.i;rgn=div6.

3. Can Ebola Virus Vaccines Have Universal Immune Correlates of protection?

4. Antibodies are necessary for rVSV/ZEBOV-GP-mediated protection against lethal Ebola virus challenge in nonhuman primates

5. Correlates of protective immunity for Ebola vaccines: implications for regulatory approval by the animal rule

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