Functional human IgA targets a conserved site on malaria sporozoites

Author:

Tan Joshua1ORCID,Cho Hyeseon2ORCID,Pholcharee Tossapol3ORCID,Pereira Lais S.4,Doumbo Safiatou5,Doumtabe Didier5ORCID,Flynn Barbara J.4,Schön Arne6ORCID,Kanatani Sachie7ORCID,Aylor Samantha O.8ORCID,Oyen David3ORCID,Vistein Rachel4ORCID,Wang Lawrence4ORCID,Dillon Marlon4,Skinner Jeff2ORCID,Peterson Mary2ORCID,Li Shanping2ORCID,Idris Azza H.49ORCID,Molina-Cruz Alvaro10ORCID,Zhao Ming11ORCID,Olano Lisa Renee11ORCID,Lee Patricia J.8,Roth Alison8ORCID,Sinnis Photini7ORCID,Barillas-Mury Carolina10ORCID,Kayentao Kassoum5ORCID,Ongoiba Aissata5ORCID,Francica Joseph R.4,Traore Boubacar5,Wilson Ian A.312ORCID,Seder Robert A.4ORCID,Crompton Peter D.2ORCID

Affiliation:

1. Antibody Biology Unit, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Rockville, MD 20852, USA.

2. Malaria Infection Biology and Immunity Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA.

3. Department of Integrative Structural and Computational Biology, Scripps Research Institute, La Jolla, CA 92037, USA.

4. Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

5. Mali International Center of Excellence in Research, University of Sciences, Technique and Technology of Bamako, BP 1805, Point G, Bamako, Mali.

6. Department of Biology, Johns Hopkins University, Baltimore, MD 21218, USA.

7. Department of Molecular Microbiology & Immunology, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe Street, Baltimore, MD 21205, USA.

8. Department of Drug Discovery, Experimental Therapeutics Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.

9. Biological Engineering Department, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

10. Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA.

11. Protein Chemistry Section, Research Technologies Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA.

12. The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.

Abstract

A functional human IgA response to malaria targets a conserved epitope in the N terminus of the Plasmodium falciparum circumsporozoite protein.

Funder

National Institutes of Health

National Institute of Allergy and Infectious Diseases

Bill and Melinda Gates Foundation

Wellcome

Military Infectious Diseases Research Program

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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