Type I interferon autoantibodies are associated with systemic immune alterations in patients with COVID-19

Author:

van der Wijst Monique G. P.123ORCID,Vazquez Sara E.4567ORCID,Hartoularos George C.23ORCID,Bastard Paul8910ORCID,Grant Tianna23ORCID,Bueno Raymund23ORCID,Lee David S.2311ORCID,Greenland John R.12ORCID,Sun Yang2311ORCID,Perez Richard213ORCID,Ogorodnikov Anton23,Ward Alyssa23,Mann Sabrina A.714ORCID,Lynch Kara L.1516ORCID,Yun Cassandra1516ORCID,Havlir Diane V.17ORCID,Chamie Gabriel17,Marquez Carina17,Greenhouse Bryan17ORCID,Lionakis Michail S.18ORCID,Norris Philip J.151619ORCID,Dumont Larry J.202122ORCID,Kelly Kathleen20ORCID,Zhang Peng10ORCID,Zhang Qian10ORCID,Gervais Adrian910ORCID,Le Voyer Tom910ORCID,Whatley Alexander23,Si Yichen24ORCID,Byrne Ashley14ORCID,Combes Alexis J.112526ORCID,Rao Arjun Arkal112526ORCID,Song Yun S.142327ORCID,Fragiadakis Gabriela K.31126ORCID,Kangelaris Kirsten28,Calfee Carolyn S.29,Erle David J.21115ORCID,Hendrickson Carolyn29ORCID,Krummel Matthew F.1125ORCID,Woodruff Prescott G.1129ORCID,Langelier Charles R.30ORCID,Casanova Jean-Laurent891031ORCID,Derisi Joseph L.714ORCID,Anderson Mark S.632ORCID,Ye Chun Jimmie23111433ORCID,

Affiliation:

1. Department of Genetics, University of Groningen, University Medical Center Groningen, 9713AV Groningen, Netherlands.

2. Institute of Human Genetics, University of California, San Francisco, San Francisco, CA 94143, USA.

3. Division of Rheumatology, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.

4. Medical Scientist Training Program, University of California, San Francisco, San Francisco, CA 94143, USA.

5. Tetrad Graduate Program, University of California, San Francisco, San Francisco, CA 94143, USA.

6. Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA.

7. Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA.

8. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France.

9. University of Paris, Imagine Institute, 75015 Paris, France.

10. St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY 10065, USA.

11. ImmunoX Initiative, University of California, San Francisco, San Francisco, CA 94143, USA.

12. Department of Medicine, University of California, San Francisco, San Francisco Medical Service, San Francisco Veterans Affairs Health Care System, San Francisco, CA 94121, USA.

13. School of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.

14. Chan Zuckerberg Biohub, San Francisco, CA 94158, USA.

15. Zuckerberg San Francisco General, San Francisco, CA 94110, USA.

16. Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.

17. Division of HIV, Infectious Disease and Global Medicine, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.

18. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD 20814, USA.

19. Vitalant Research Institute, San Francisco, CA 94118, USA.

20. Vitalant Research Institute, Denver, CO 80230, USA.

21. University of Colorado School of Medicine, Aurora, CO 80045, USA.

22. Geisel School of Medicine at Dartmouth, Lebanon, NH 03755, USA.

23. Department of Electrical Engineering and Computer Sciences, University of California, Berkeley, Berkeley, CA 94720, USA.

24. Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA.

25. Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA.

26. UCSF CoLabs, University of California, San Francisco, San Francisco, CA 94143, USA.

27. Department of Statistics, University of California, Berkeley, Berkeley, CA 94720, USA.

28. Division of Hospital Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.

29. Division of Pulmonary, Critical Care, Allergy and Sleep, Department of Medicine and the Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143, USA.

30. Division of Infectious Disease, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.

31. Howard Hughes Medical Institute, New York, NY 10065, USA.

32. Division of Endocrinology and Metabolism, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.

33. Departments of Epidemiology and Biostatistics and Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA 94143, USA.

Abstract

Type I interferon autoantibodies in patients with COVID-19 are associated with poor interferon responses and increased LAIR1 abundance in leukocytes.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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