Selective targeting of NaV1.7 via inhibition of the CRMP2-Ubc9 interaction reduces pain in rodents-Reference-Cited by-同舟云学术

Selective targeting of NaV1.7 via inhibition of the CRMP2-Ubc9 interaction reduces pain in rodents

Published:2021-11-10 Issue:619 Volume:13 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Cai Song¹^ORCID,Moutal Aubin¹^ORCID,Yu Jie¹^ORCID,Chew Lindsey A.¹^ORCID,Isensee Jörg²^ORCID,Chawla Reena³,Gomez Kimberly¹^ORCID,Luo Shizhen¹^ORCID,Zhou Yuan¹^ORCID,Chefdeville Aude¹^ORCID,Madura Cynthia¹^ORCID,Perez-Miller Samantha¹⁴^ORCID,Bellampalli Shreya Sai¹^ORCID,Dorame Angie¹,Scott David D.¹,François-Moutal Liberty¹^ORCID,Shan Zhiming¹,Woodward Taylor⁵^ORCID,Gokhale Vijay³⁶^ORCID,Hohmann Andrea G.⁵^ORCID,Vanderah Todd W.¹⁷,Patek Marcel⁸⁹^ORCID,Khanna May¹³⁴⁸^ORCID,Hucho Tim²^ORCID,Khanna Rajesh¹³⁴⁷⁸^ORCID

Affiliation:

1. Department of Pharmacology, College of Medicine, The University of Arizona, Tucson, AZ 85724, USA.

2. Department of Anesthesiology and Intensive Care Medicine, Translational Pain Research, University Hospital of Cologne, University Cologne, Joseph-Stelzmann-Str 9, Cologne D-50931, Germany.

3. BIO5 Institute, 1657 East Helen Street, Tucson, AZ 85721, USA.

4. Center for Innovation in Brain Sciences, University of Arizona, Tucson, AZ 85721, USA.

5. Department of Psychological and Brain Sciences, Program in Neuroscience and Gill Center for Biomolecular Science, Indiana University, Bloomington, IN 47405-2204, USA.

6. College of Pharmacy, University of Arizona, 1703 East Mabel Street, Tucson, AZ 85721, USA.

7. Comprehensive Pain and Addiction Center, The University of Arizona, Tucson, AZ 85724, USA.

8. Regulonix LLC, 1555 E. Entrada Segunda, Tucson, AZ 85718, USA.

9. Bright Rock Path LLC, Tucson, AZ 85724, USA.

Abstract

Protein-protein interaction inhibitor of the sodium NaV1.7 channel has analgesic effects in preclinical models of pain.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference90 articles.

1. The role of Nav1.7 in human nociceptors: insights from human induced pluripotent stem cell–derived sensory neurons of erythromelalgia patients