Modulation of prefrontal cortex excitation/inhibition balance rescues social behavior in CNTNAP2 -deficient mice-Reference-Cited by-同舟云学术

Modulation of prefrontal cortex excitation/inhibition balance rescues social behavior in CNTNAP2 -deficient mice

Published:2017-08-02 Issue:401 Volume:9 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Selimbeyoglu Aslihan¹,Kim Christina K.¹,Inoue Masatoshi²^ORCID,Lee Soo Yeun²³,Hong Alice S. O.²^ORCID,Kauvar Isaac⁴,Ramakrishnan Charu²^ORCID,Fenno Lief E.²³^ORCID,Davidson Thomas J.²³^ORCID,Wright Matthew³,Deisseroth Karl²³⁵^ORCID

Affiliation:

1. Neuroscience Program, Stanford University, Stanford, CA 94305, USA.

2. Department of Bioengineering, Stanford University, Stanford, CA 94305, USA.

3. Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, USA.

4. Department of Electrical Engineering, Stanford University, Stanford, CA 94305, USA.

5. Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.

Abstract

Using optogenetics to modulate the excitation/inhibition balance in the prefrontal cortex of an autism-like mouse model rescued social behavior deficits.

Funder

Howard Hughes Medical Institute

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference46 articles.

1. The Emerging Picture of Autism Spectrum Disorder: Genetics and Pathology

2. American Psychiatric Association Diagnostic and Statistical Manual of Mental Disorders: DSM-5 (American Psychiatric Association Publishing 2013).

3. Optogenetics and the Circuit Dynamics of Psychiatric Disease

4. Model of autism: increased ratio of excitation/inhibition in key neural systems

5. Minicolumnar pathology in autism

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