BET bromodomain inhibition suppresses innate inflammatory and profibrotic transcriptional networks in heart failure

Author:

Duan Qiming1ORCID,McMahon Sarah1ORCID,Anand Priti1,Shah Hirsh2,Thomas Sean1ORCID,Salunga Hazel T.1ORCID,Huang Yu1,Zhang Rongli2ORCID,Sahadevan Aarathi2,Lemieux Madeleine E.3,Brown Jonathan D.4ORCID,Srivastava Deepak15,Bradner James E.6ORCID,McKinsey Timothy A.7,Haldar Saptarsi M.18ORCID

Affiliation:

1. Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA.

2. Institute for Transformative Molecular Medicine and Department of Medicine, Case Western Reserve University School of Medicine and University Hospitals Cleveland Medical Center, Cleveland, OH 44106, USA.

3. BioInfo, Plantagenet, Ontario K0B 1L0, Canada.

4. Division of Cardiovascular Medicine, Department of Medicine, and Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.

5. Division of Cardiology, Department of Pediatrics, University of California San Francisco School of Medicine, San Francisco, CA 94158, USA.

6. Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02215, USA.

7. Division of Cardiology, Department of Medicine, Consortium for Fibrosis Research & Translation, University of Colorado, Anschutz Medical Campus, Denver, CO 80204, USA.

8. Division of Cardiology, Department of Medicine, and Cardiovascular Research Institute, University of California San Francisco School of Medicine, San Francisco, CA 94158, USA.

Abstract

BET bromodomain inhibition treats heart failure by blocking innate inflammatory and profibrotic gene networks.

Funder

National Heart, Lung, and Blood Institute

National Institute of Diabetes and Digestive and Kidney Diseases

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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