A role for bacterial urease in gut dysbiosis and Crohn’s disease

Author:

Ni Josephine1ORCID,Shen Ting-Chin David1,Chen Eric Z.2,Bittinger Kyle3,Bailey Aubrey4ORCID,Roggiani Manuela5,Sirota-Madi Alexandra6ORCID,Friedman Elliot S.1ORCID,Chau Lillian1,Lin Andrew1ORCID,Nissim Ilana7,Scott Justin6ORCID,Lauder Abigail4ORCID,Hoffmann Christian4ORCID,Rivas Gloriany8ORCID,Albenberg Lindsey9ORCID,Baldassano Robert N.9ORCID,Braun Jonathan10ORCID,Xavier Ramnik J.61011ORCID,Clish Clary B.6ORCID,Yudkoff Marc7ORCID,Li Hongzhe2ORCID,Goulian Mark5ORCID,Bushman Frederic D.4,Lewis James D.12ORCID,Wu Gary D.1ORCID

Affiliation:

1. Division of Gastroenterology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

2. Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

3. Division of Gastroenterology, Hepatology, and Nutrition, The Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA.

4. Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

5. Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA.

6. Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard University, Cambridge, MA 02142, USA.

7. Division of Child Development, Rehabilitation, and Metabolic Disease, The Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA.

8. Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

9. Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.

10. Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

11. Center for Microbiome Informatics and Therapeutics, MIT, Cambridge, MA 02139, USA.

Abstract

Bacterial urease activity of the gut microbiota alters nitrogen flux, leading to gut dysbiosis and worsening of colitis in mice.

Funder

National Institutes of Health

NIH Office of the Director

Crohn’s and Colitis Foundation of America

NIH

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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